摘要
【目的】结合文献复习,提出胰高糖素瘤综合征的临床诊断和治疗策略。【方法】回顾分析了本院1例具有典型坏死松解游走性红斑、糖尿病、舌炎、消瘦、贫血等表现的胰高糖素瘤患者的临床资料。【结果】反复好发于臀部、腹股沟、会阴、下肢、口角等处的皮肤坏死溶解性迁徙性红斑是胰高糖素瘤最具特征的临床表现,放射免疫法测定血胰高糖素显著升高。手术切除后,并以生长抑素(善宁)治疗两周,临床症状明显改善。皮疹在术后10d基本消退。【结论】依据其最具特征的临床表现及糖尿病症状,结合血胰高糖素的测定和影像学检查可明确胰高糖素瘤的诊断。对于没有胰外浸润及转移的胰高糖素瘤手术切除为首选,并应尽早发现和治疗。
[Objective]To assess the clinical diagnosis and treatment of glucagonma syndrome. [Methods]The clinical data of a case of glucagonoma with typical necrolytic migratory erythema （NME）, diabetes mellitus （DM）, glossitis, weight loss, anemia and anxiety were retrospectively analyzed. [Results] The NME was the distinctive feature of glucagonoma. The typical eruption occurred mainly in the buttocks, groin, perineum, extremities, and cheilion. A highly elevated level of serum glucagons was detected in this patient. This patient was treated with somatostatin for two weeks. All symptoms were significantly improved. [Conclusion]The clinical diagnosis of glucagonoma syndrome is established by marked clinical features, and hyperglucagonemia and the imaging methods. Enucleation of tumor is a valuable treatment for solitary pancreatic tumor without peripancreatic invasion or liver metastasis. It should be found and treated as early as possible.
出处
《医学临床研究》
CAS
2008年第10期1773-1776,共4页
Journal of Clinical Research
