摘要
目的:观察气血并治方胶囊治疗颈动脉粥样硬化(CAS)的临床疗效并探讨其可能的作用机理。方法:CAS患者100例随机分为两组:对照组(50例)给予西医常规治疗,治疗组(50例)在西医常规治疗的基础上给予气血并治方胶囊,连续服用3个月,治疗前后对患者进行血瘀证积分统计,并测定患者血脂、高敏C-反应蛋白(hs-CRP)、血栓素B2(TXB2)和6-酮-前列腺素PGF1α(6-Keto-PGF1α)的含量。结果:气血并治方胶囊可以改善患者血瘀证积分,降低甘油三脂、低密度脂蛋白,升高高密度脂蛋白,减少hs-CRP水平,抑制TXB2合成、增加PGF1α水平,与对照组相比,有显著性差异(P<0.01,P<0.05)。结论:气血并治方胶囊能有效地改善CAS患者的临床症状,调节患者脂质代谢,降低患者血浆炎性因子hs-CRP含量。
Objective：To observe the clinical effects of capsule of regulating qi and xue recipe （CRQXR）on carotid artery atherosclerosis （CAS）and discuss the mechanisms. Methods：100 cases of CAS were divided into 2 groups randomly,the regular western medicine group （50 cases）and CRQXR with regular western medicine group. Blood stasis syndrome score was evaluated before and after treatment respectively after 3-month treatment. The content of blood lipid,high sensitive C- reactive protein （hs-CRP）,thromboxan B2 （TXB2）aud 6-ketone-prostaglandin F1α （6-Keto-PGF1α）was detected. Results：CRQXR could decrease blood stasis score, triglyceride （TG）,low density lipoprotein （LDL）and hs-CRP,increase high density lipoprotein（HDL）and PGF1α;and intervere the synthetization of TXB2 of significant difference（P〈0.01,P〈0.05）. Conclusion：CRQXR could relieve the clinical symptoms and regulate lipid metabolism and decrease hs-CRP.
出处
《世界中西医结合杂志》
2008年第1期29-31,47,共4页
World Journal of Integrated Traditional and Western Medicine
基金
国家重点基础研究发展规划资助项目(No.G1999054405)
关键词
中西医结合
气血并治方
血府逐瘀汤
颈动脉粥样硬化
血瘀证
The integration of traditional and western medicine
CRQXR
xuefuzhuyu decoction
carotid artery atherosclerosis
blood stasis syndrome
