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正交试验设计优选紫草的醇提工艺 被引量:14

Optimization on Alcohol Extraction Technology of Radix Arnebiae by Orthogonal Design
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摘要 目的:优选紫草中左旋紫草素等萘醌类成分的最佳提取工艺。方法:采用L9(34)正交试验法,以左旋紫草素量和干浸膏得率为评价指标,考察乙醇用量、提取温度和提取时间3个因素,每个因素选取3个水平进行试验。结果:提取温度对紫草有效成分的提取有显著影响,最佳提取工艺为:加入12倍和10倍量95%乙醇,在65℃条件下温浸提取两次,每次1h。结论:优选得到的工艺稳定、合理可行。 OBJECTIVE: To optimize the extraction technology of naphthoquinone such as L- shikonin in Radix Arnebiae. METHODS: An L9 (34) orthogonal experiment was performed to investigate the 3 factors (three levels for each factors were selected), i.e. the amount of ethanol, temperature and time of extraction with the quantity of L - shikonin and extracta sicca yield as indexes for evaluation. RESULTS: The temperature of extraction had significant impact on the extraction of the effective components in Radix Arnebiae. The best extraction technology was as follows: adding 12 - fold and 8 - fold ethanol solution (at a concentration of 95% ) for digeratur extraction twice at 65℃(1.0 h each time ). CONCLUSION: The optimized technology for the extraction of L - shikonin from Radix Arnebiae was stable, reasonable and feasible.
作者 吴学渊 刘萍
出处 《中国医院用药评价与分析》 2008年第10期750-752,共3页 Evaluation and Analysis of Drug-use in Hospitals of China
基金 解放军总医院新药研发基金(NDR0706)
关键词 紫草 左旋紫草素 正交试验 提取工艺 Radix Amebiae L - shikonin Orthogonal experiment Extraction technology
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