摘要
目的：观察吉西他滨和顺铂联合放疗治疗中晚期鼻咽癌的临床疗效及其毒副反应。方法：2006年1月至2007年12月对39例鼻咽癌采取吉西他滨1 000mg/m^2,d1、8,顺铂20mg/m^2,d1-5,每3周为一周期,两周期后序贯放疗70～72Gy/7～8周。结果：39例患者中,CR16例,PR18例,有效率为87.1%,主要毒副作用是骨髓抑制,其他毒副作用均较轻,可耐受,不影响治疗。结论：吉西他滨和顺铂联合放疗治疗中晚期鼻咽癌是一较好方案,毒副反应较轻。
Objective： Objective To evaluate the efficiency and toxicity of Gemcitabine and Cisplatin with radiotherapy in the treatment of nasopharyngeal carcinoma.Methods： From January 2006 to December 2007,39 patients with nasopharyngeal poorly differentiated squamous cell cancer were enrolled in study. Gemcitabine 1000mg/m^2,dl ,8 ; Cisplatin 20mg/m^2, dl - 5, every 3 weeks, after 2 cycle, radiotherapy 70 - 72Gy/7 - 8weeks. Results： All eligible patients were assessed for response and 16 achieved a complete response, 18 achieved a conform partial response; the total response rate is 87.1%, Toxicity was mainly related to myelosuppression. Other toxicity was relatively lighter. Conclusion： Gemcitabine and Cisplatin with radiotherapy represents a well- tolerated active regimen for patients with squamous cell carcinoma of the nasopharynx.
出处
《中国民康医学》
2008年第20期2360-2361,共2页
Medical Journal of Chinese People’s Health
关键词
鼻咽癌
吉西他滨
顺铂
放疗
化疗
毒副反应
Nasopharynx
Gemcitabine
Cisplatin
radiotherapy
Chemotherapy
Toxic side effects.
