摘要
采用放射免疫测定方法 (RIA) ,观察 4 3例糖尿病患者血、尿 α1-微球蛋白 (α1- MG)、β2 -微球蛋白 (β2 - MG)及血肌酐 (SCr)变化。结果显示 :常规尿蛋白阴性 ,SCr含量异常者占 2 5.5% ,尿中 α1- MG/ Cr、β2 - MG/ Cr、血 α1- MG、β2 - MG异常者分别占 79.0 7%、6 7.4 4 %、37.2 1%、55.81%。各种微球蛋白测定的阳性率与 SCr比较 ,差异有显著性 (P<0 .0 0 5)。结果说明血、尿 α1- MG、β2 -MG在诊断糖尿病早期肾损伤中有一定的临床意义。并提示血尿α1- MG、β2 - MG测定在反映肾脏损伤中比
diabetes patients were observed for the alternation of blood,urine α 1 microglobulin(α 1 MG),β 2 microglobulin (β 2 MG) and serum creatinine(SCr) by radioactive immunity assay(RIA).The results showed that the routine contents of negative urine protein and SCr were 25.5% higher than those normal positive rates.α 1 MG and β 2 MG in urine,α 1 MG and β 2 MG in blood were 79.04%,67.44%,37.21%,55.81% higher respectively than those of normal positive rates,the difference was remarkable ( P <0.005).It indicated that α 1 MG and β 2 MG in blood and urine had certain clinical significance in the early diagnosis of diabetic kidney injury.It is suggested that the detection show more sensitivity than serum creatinine in the kidney injury.
出处
《洛阳医专学报》
1997年第4期240-242,共3页
Journal of Luoyang Medical College
