摘要
目的探讨持续静脉滴入氟尿嘧啶(5-FU)和卡培他滨分别与奥沙利铂(L-OHP)联合对晚期胃癌的效果。方法67例晚期胃癌患者分别接受A组方案(32例)和B组方案(35例)治疗。A组方案(OX):奥沙利铂L-OHP 130 mg/m2,静脉滴入(2 h),d1;卡培他滨1 000 mg/m2,口服,每天2次,共14天。B组方案(mFOLFOXseven):奥沙利铂L-OHP 100 mg/m2,静脉滴A(2 h),d1;LV(亚叶酸钙)200 mg/m2,静脉滴注入(2h),d1;5-FU2.4/m2,持续静脉滴注,46小时。均21 d为一个周期。结果67例患者中CR 3例,PR 40例,有效率64.0%TTP(中位至肿瘤进展时间)和MST(中位生存期)分别为7.5个月和11.2个月。方案A有效率高于方案B,分别为68.8%和60.0%,但差异无统计学意义(χ2=0.557,P=0.456)。两种治疗方案的不良反应均易于耐受。结论持续静脉滴入氟尿嘧啶和卡培他滨分别与奥沙利铂联合可作为晚期胃癌安全有效的治疗方案。
Objective To study the effects of continu-ous intravenous infusional （CIV） 5-fluorouracil （5-FU） combined with oxaliplatin in the treatment of advanced gastric cancer. Methods Sisty-seven advanced gastric cancer patients were treated with regimen A or regimen B. Regimen A （OX） ： L-OHP 130 mg/m^2iv （2h）, dl ; capecitabine 1000 mg/m^2 , po. bid. dl-14 ; Regimen B （mFOLFOXseven）： L-OHP100 mg/m^2iv （2h）, dl; LV200 mg/m^2, iv （2 h）, dl; 5-FU 2.4/m^2CIV （46 h） Regimen A and B were repeatedevery 21 days. Results There were3 CR. 40 PR cases in the 67 patients Response rate （RR） was 64.0%TTP （a time to pro-gression） and MST （median survival time） were 7.5 months and 11.2 months respectively. The RRs of regimen A and B were 68.8%and 60.0% respectively. The difference did not reach the Icyel of statistical significance （X^2 =0. 557, P=0. 456） . The adverse effects of the two regimens were mild. Conclusions The ragiment of continuous intravenous infu-sional （CIV） 5-fluorouracil （5-FU） orcapecitabine combined withoxaliplatin for advanced gastric carlcer is safe and effective.
出处
《福建医药杂志》
CAS
2008年第5期114-116,共3页
Fujian Medical Journal
关键词
胃肿瘤
奥沙利铂
仁培他滨
Stomach neoplasms
oxaliplatin
capetitabine
