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EphA_2与肿瘤 被引量：5

EphA_2 and tumor
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摘要 酪氨酸蛋白激酶受体(receptor tyrosine kinases,RTKs)参与细胞增生和分化、胚胎发育和细胞内信号转导等过程,具有重要的生理功能。生促红素人肝细胞(erythropoietin-producing human hepatocelluar,Eph)A2是Eph受体酪氨酸蛋白激酶家族RTKs中的一员,广泛表达在人类多种组织或细胞系中,对调节细胞生长、迁移及血管形成有潜在的作用。EphA2过表达可导致细胞的恶性转化,增强肿瘤细胞的侵袭性和转移性。EphA2有望成为恶性肿瘤治疗的新的靶点和预后指标。 Receptor tyrosine kinases （RTKs） are involved in cellular growth, differentiation, embryonic development,and intracellular signalling pathways, and possess important physiological functions. EphA2 belongs to Eph receptor tyrosine kinase family （RTKs） , widely expressed in human tissues and plays a role in regulating cell growth, migration and angiogenesis. Recent studies have shown that its over-expression can lead to the cell＇ s malignant transformation and enhance the invasive of tumor cells. Therefore, EphA2 may become a malignant tumor prognostic indicator, and a new cancer therapy target.
作者 蒋莎莉 罗招阳
机构地区 郴州市第一人民医院病理科 南华大学肿瘤研究所
出处 《国际病理科学与临床杂志》 CAS 2008年第5期412-415,共4页 Journal of International Pathology and Clinical Medicine
关键词 生促红素人肝细胞A2 酪氨酸蛋白激酶受体 肿瘤 EphA2 receptor tyrosine kinases（RTKs） neoplasm
分类号 R730.2 [医药卫生—肿瘤]
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共引文献28

同被引文献29

  • 1冯延平,黄涛,高军,常青,秦仁义.EphA2与E-cadherin在胰腺癌中的表达及其意义[J].中国普通外科杂志,2005,14(12):914-917. 被引量：8
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  • 9Kunishio K, Okada M, Matsumoto Y, et al. Matrix metalloproteinase-2 and -9 expression in astrocytic tumors [J]. Brain Tumor Pathol, 2003, 20(2):39-45.
  • 10Nakada M, Kita D, Futami K, et al. Roles of membrane type-1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of hu- man malignant glioma[J].J Neurosurg,2001,94(3):464-473.

引证文献5

二级引证文献10

国际病理科学与临床杂志
2008年 第5期

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