摘要
目的观察中药灌肠对慢性肾衰竭患者肾功能及血TGF-β1的影响。方法共观察病例43例,随机分为治疗组22例,对照组21例,均符合慢性肾衰竭诊断,中医辨证属脾肾阳虚证,两组患者均采用一般对症处理,包括控制血压,纠正酸碱失衡,优质低蛋白饮食、低磷饮食等。治疗组患者在此基础上加用中药灌肠治疗,14d为一疗程,共治疗2个疗程。观察两组患者血肌酐(Scr)、尿素氮(Bun)及TGF-β1的变化。结果治疗组在改善肾功能,降低Bun、Scr、TGF-β1方面优于对照组,有非常显著性差异(P<0.01)。治疗组在改善临床症状方面,疗效明显优于对照组,有显著性差异(P<0.05)。结论中药灌肠能够改善慢性肾衰竭患者的肾功能和临床症状,而降低TGF-β1、抑制细胞外基质聚集、延缓肾小球硬化可能是其作用机理之一。
Objective To observe the effect on transforming growth factor β1（TGF-β1）and kidney function in chronic renal failure patients by using TCM enema. Methods There were 43 cases in total,which were randomly divided into therapy group（ 22 cases ） and control group （21 cases）. All patients were accord with the diagnosis of chronic renal failure,and the TCM syndrome differentiation belonged to Yang deficiency of spleen and kidney. Both groups were applied with general expectant treatment, including blood pressure control, acid-base imbalance adjustment,high quality low-protein diet,low-phosphate diet etc. For therapy group,we administrated TCM enema treatment besides the general care, 14 days as a treatment course, totally 2 courses was applied. Alternations of serum creatinine（Scr）, blood urea nitrogen （BUN） and TGF- β1 in both groups were recorded. Results The therapy group can improve the kidney function. It has better effect on decreasing Bun, Scr and TGF- β1 with significant difference when compared with control group（P〈 0.01 ）. Moreover, therapy group can improve the clinical syndromes as well.which was obviously better than the control with significant difference（P〈 0.01 ）. Conclusion TCM enema can improve the kidney function and clinical symptom for chronic renal failure patients. And decreasing of TGF- β1, inhibition the accumulation of extracellular matrix and delaying of glomerulosclerosis may be the mechanism of its effect.
出处
《中国现代医生》
2008年第31期4-5,共2页
China Modern Doctor
关键词
慢性肾衰竭
肾功能
TGF—β1
中药
灌肠
Chronic renal failure
Kidney function
TGF- β1
Traditional Chinese Medicine（TCM ）
Enema
