摘要
目的研究鲜鱼腥草提取物对脂多糖所致小鼠肺部炎症的影响。方法采用ICR小鼠鼻滴脂多糖(LPS)建立肺部炎症模型,检测小鼠支气管肺泡灌洗液(BALF)中炎症细胞数和病理学观察肺组织炎症程度。结果鲜鱼腥草提取物40～400mg·kg-1可减少小鼠LPS所致的BALF中白细胞增高,还可减轻肺组织病理炎症细胞浸润。结论鲜鱼腥草提取物可以减轻LPS所致的小鼠肺部炎症反应,减少炎症细胞浸润。提示鲜鱼腥草提取物对脂多糖所致小鼠肺部炎症有抑制作用。
OBJECTIVE To study the effect of fresh herba houttuyniae extract on lipopolysaccharide （LPS）-induced lung inflammation in mice. METHODS ICR mice were injected with LPS through nose to establish lung inflammation model. The number of inflammatory ceils in brochoalveolar lavage fluid（BALF） was examined, and the degree of the inflammation of lung tissne by pathology was observed. RESULTS 40 -400 mg·kg^-1 of Fresh herba houttuyniae extract reduced the increase of LPS-induced leucocytes in BALF in mice, and alleviated the infiltration of inflammatory cells in pathological lung tissue. CONCLUSION Fresh herba houttuyniae extract can alleviate LPS-induced lung inflammation,and reduce the infiltration of inflammatory cells,which show that fresh herba houttuyniae extract inhibits the LPS-induced lung inflammation in mice.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2008年第5期376-378,共3页
Chinese Journal of Modern Applied Pharmacy
基金
浙江省中医药管理局课题(2004C138)
杭州市科技局医学重点专科专病支助项目(2005633Q29)
关键词
鱼腥草提取物
脂多糖
肺部炎症
Herba houttuyniae extract
lipopolysaccharide
lung inflammation
