摘要
目的:探索银屑病皮损组织中热休克蛋白60(HSP60)、热休克蛋白90(HSP90)与糖皮质激素受体活性的相关性。方法:采用免疫组化方法检测银屑病患者皮损组织中HSP60、HSP90和糖皮质激素受体(GR)的表达,并作相关性分析。结果:银屑病皮损组织中HSP60、HSP90明显表达,GR有较低水平表达,HSP60、HSP90与GR呈负相关,相关系数分别为-0.77457与-0.74252。结论:银屑病皮损组织中HSP60、HSP90与GR的活性有一定的关系,可能在银屑病发病和病程演变中起一定的作用。
Objective：To investigate the correlation between expression of HSP60, HSP90 and activity of glucocorticoid receptor （GR） in psoriatic lesion tissue. Methods：The expressions of HSP60 and HsPg0 and the activity of GR in psoriatic lesion tissue were detected by immunohistoehemistry. The correlation between them was analyzed according to the results. Results： HSP60 and HSP90 expressed remarkably in psoriatic lesion tissue, while GR expression was lower. HSP60, HSP90 and GR demonstrated negative correlation. The correlative coefficient was -0. 77457 and-0. 74252, respectively. Conclusion： There is negative correlation between the expression of HSP60, HSP90 and activity of glucoeortieoid receptor in psoriatic lesion tissue, which may be related with the development of psoriasis.
出处
《西南国防医药》
CAS
2008年第6期830-831,共2页
Medical Journal of National Defending Forces in Southwest China
