摘要
目的:观察甘氨双唑钠(CMNa)对Ⅲ期非小细胞肺癌(NSCLC)三维适形放疗(3-DCRT)的放射增敏作用及其安全性。方法:经病理和细胞学确诊的Ⅲ期NSCLC患者120例,采用随机双盲对照法分为A组(放疗+CMNa组)45例和B组(放疗+安慰剂组)45例。A组用CMNa1000mg/次,3次/周(星期一、三、五用药);CMNa溶于100mL生理盐水中,30min内滴完;B组用安慰剂加生理盐水,方法同A组,直至疗程结束。输液结束后30～60min内两组进行3-DCRT,每周5次,每次2Gy,总剂量为60～70Gy。结果:A组CR率和总有效率(CR+PR)均明显高于B组;A组患者治疗达到PR和CR时的平均照射剂量均低于B组;两组患者不良反应发生率的比较差异无统计学意义,P=0.54。结论:CMNa对Ⅲ期NSCLC3-DCRT有较肯定的放射增敏作用,明显提高了NSCLC的近期疗效,不增加不良反应。
OBJECTIVE： To observe radiosentization and security of three-dimensional confonnal radiotherapy （3-DCRT）to non-small cell lung cancer（NSCLC） stage Ⅲ with glycididazole natrium （CMNa）. METHODS： A total of 120 cases of NSCI.C in stage Ⅲ were divided into Group A （45 cases, radiotherapy＋CMNa）and Group B （45 cases, radiotherapy ＋ placebo） randomly. CMNa was given 1 000 mg per fractio for A group, 3 times a week（Monday, Thursday, Friday）in solution of 100 mL normal saline, iv drip within 30 minutes; placebo was given for B group. Three-dimensional conformal radiotherapy was started 30--60 minutes after completion of the infusion, 5 times each week, and radiotherapy was given by conventional schedule： 2.0 Gy per fraction, 5 times per week to a total dose of 60--70 Gy/6--7 weeks. RESULTS： The rate of CR and total effective rate（CR＋PR） were significantly higher in Gruop A than those in Group B. The median doses by which the effects had reached PR and CR respeetively were lower in Group A than in Group B. There was no significant difierence between the two groups in the rate of adverse reaction, P= 0.54. CONCLUSIONS： CMNa is radiosentizative to NSCLC in stage Ⅲ with 3-DCRT. It could increase the therapeutic result of NSCLC without severe toxicities.
出处
《中华肿瘤防治杂志》
CAS
2008年第17期1342-1344,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
癌
非小细胞肺/放射疗法
三维适形放疗
甘氨双唑钠
放射增敏
carcinoma, non-small cell lung/radiotherapy
three dimensional conformal radiotherapy
glycididazole natrium
radiosensitization
