摘要
目的观察静脉注射左卡尼汀对维持性血液透析（MHD）患者炎症状态的影响。方法选择透析龄超过2个月的MHD患者42例，每次透析结束后，静脉注射左卡尼汀1g，随访6个月，分别检测治疗前、治疗后1个月、治疗后6个月患者的主要血生化指标、C反应蛋白、自介素26等。结果治疗1个月后，MHD患者透析后干体重有上升；治疗6个月后，患者平均干体重较治疗前显著升高（P〈0．05），血白蛋白、前白蛋白和血红蛋白较治疗前明显升高（P〈0．05，P〈0．01），（反应蛋白、白介素26）等平均值均较治疗前明显下降（P〈0．01），血总胆固醇、三酰甘油水平治疗前后无显著差异。结论左卡尼汀可使MHD患者的炎症状态明显好转，有效改善患者的营养状态。
Objective To investigate the effect of levocarnitine on nutrition, microirnflammation status in maintenance hemodialysis （MHD） patients. Methods Forty two MHD patients were selected,who had undergone hemodialysis for at least two months before the study. One gram of levocamitine was injecfed to the patients at the end of each dialysis treatment for six months. The parameters of inflammation stress were studied. Results After treatment with levocarnitine for six months, the average levels of dry body weight decreased markedly. （P 〈 0. 05）, The average serum levels of C2reactive protein （CLIP）,interleukin26 （IL26） ,tumor necrosis factor2α （ TNF2α）, （P 〈 0. 01）. Difference was not significant between serum lipid parameters before and after the treatment. Conclusion Intravenous supplement with levocarnitine in MHD patients, appears to be associated with an improvement of nutrition and microinflammation status.
出处
《中国基层医药》
CAS
2008年第10期1669-1670,共2页
Chinese Journal of Primary Medicine and Pharmacy
