摘要
脐带血含有丰富的造血干细胞,已经成为替代骨髓移植治疗多种疾病的良好资源,但尚存多种不足与难题。国内外大量研究证实,脐带血干细胞具有肯定的支持造血功能,在体外培养条件下可以扩增,并且在一定的诱导作用下可分化为骨、软骨、肝、内皮等多种组织细胞。脐带血干细胞具有低免疫原性等很多优点,已成为干细胞研究领域的热点。目前分离培养脐带血干细胞的方法多样,日趋成熟,临床应用脐带血干细胞移植治疗的疾病已达80余种,但仍存在许多弊端,尚需进一步的研究。
Abstract： Umbilical cord blood includes plenty of hematopoietic stem cells. It has already become good resources that substitutes bone marrow transplantation to treat many kinds of diseases. But, there are many insufficiencies and difficulties. Massive domestic and foreign experiments have confirmed that umbilical cord blood stem cell has the affirmative support hemopoiesis function, may expand under in vitro condition, and can differentiate into bone, cartilage, liver, bast and so on under a certain induction. Umbilical cord blood stem cells with low immunogenicity have been a key focus in stem cell research. Presently, the isolated culture method of umbilical cord blood stem cells is diverse and mature. In clinic, umbilical cord blood stem cell transplantation can treat 80 kinds of diseases, but still have many malpractices, and needs the further research.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第43期8553-8556,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
