摘要
目的探讨奋乃静、利培酮对中老年精神分裂症患者体质量、糖脂代谢、催乳素及肿瘤坏死因子α的影响。方法将49例中老年精神分裂症患者随机分为奋乃静组(23例)和利培酮组(26例),共治疗8周。所有患者于疗前和治疗8周后测定体质量、空腹血糖、胰岛素、血脂和肿瘤坏死因子α水平。奋乃静组19例和利培酮组21例完成疗前和治疗8周后血清催乳素测定。结果治疗8周后,奋乃静组和利培酮组体质量、血清催乳素水平均显著增加,前组甘油三酯水平显著增高,后组高密度脂蛋白和空腹血糖水平显著降低。两组胰岛素、胰岛素抵抗及血清肿瘤坏死因子水平治疗8周前后无显著性差异。结论奋乃静和利培酮均可导致中老年精神分裂症患者体质量、血清催乳素水平显著增加,但两种药物对糖脂代谢的影响并不相同。
Objective To explore the effets of perphenazine and risperidone on body weight,glucose and lipid metabolism, prolacfin and tumor necrosis factor ot in the middle-aged and aged inpatiems with schizophrenia. Methods 49 inpafients with schizophrenia were randomly divided into perphenazine group （rt = 23 ） and risperidone group （n = 26） for eight weeks. Body weight, fasting blood glucose, insulin, blood lipids and tumor necrosis factor a were determined in all inpatients before treatment and after eight-week treatment. In 19 inpatients of perphenazine group and 21 inpatients of risperidone group,serum prolactin were determined before treatment and after eight-week treatment. Results After eight-week treatment, the body weight and serum prolactin levels increased significantly in both groups, the levels of blood triglyceride increased significantly in perphenazine group, the levels of blood high density lipoprotein and fasting blood glucose decreased significantly in risperidone group. The changes of the insulin, insulin risistance and serum tumor necrosis factor ot showed no significant difference in both groups. Conclusion Both perphenazine and risperidone can increase body weight and the serum prolactin levels, but perphenazine and risperidone differ in their effct on glucose and lipid metabolism.
出处
《四川精神卫生》
2008年第4期193-195,共3页
Sichuan Mental Health
关键词
奋乃静
利培酮
精神分裂症
糖脂代谢
催乳素
肿瘤坏死因子α
Perphenazine Risper/done Schizophrenia Body weight glucose and lipid metabolism Prolacfin Tumor necrosis factor α
