摘要
目的 探讨2型糖尿病合并脑卒中患者的认知功能改变特点。方法对34例2型糖尿病患者与67例非糖尿病患者在发生脑卒中后3周、6个月及12个月进行简易智能精神状态检查量表（MMSE）及蒙特利尔认知评估量表（MOCA）测评，并对评分进行比较。结果糖尿病组在脑卒中后3周、6个月及12个月的MMSE、MOCA平均得分均低于非糖尿病组，除脑卒中后12个月的MMSE评分外（P〉0．05），糖尿病组其他各项评分与非糖尿病组比较，组间差异均有统计学意义（P〈0．05）。糖尿病组在脑卒中后3周与6个月的MMSE和MOCA评分差异均无统计学意义（P〉0．05），6个月与12个月的MMSE和MOCA评分差异均有统计学意义（P〈0．05）。非糖尿病组在脑卒中后3周、6个月及12个月的MMSE和MOCA评分，组内差异均无统计学意义（P〉0．05）。结论2型糖尿病会加重脑卒中患者的认知功能损害，其认知功能障碍的恢复于脑卒中6个月后开始，不同于脑卒中后肢体障碍恢复的时间特点。
Objective To investigate the characteristics of cognitive changes in type 2 diabetes mellitus patients complicated with stroke. Methods One hundred and one stroke patients were recruited and allocated to the type 2 diabetes mellitus group （34 patients） and sixty-seven patients in the control group （67 patients） according to being with or without type 2 diabetes mellitus. All the patients were evaluated, after 3 weeks, 6 months and 12 months of onset of stroke, with regard to their cognitive functions by using the Mini-mental State Examination （MMSE） and Montreal Cognitive Assessment （MOCA）. Results Average scores obtained in MMSE and MOCA tests were significantly lower at 3 weeks and 6 months after onset in the type 2 diabetes mellitus group when comparing with control group. In the type 2 diabetes mellitus group, no significant difference was observed between 3 weeks and 6 months after onset of stroke with regard to scores of MMSE and MOCA （P 〉 0. 05） , however, the score at 6 months was significantly lower than that at 12 months after onset （ P 〈 0. 05 ）. On the other hand, scores of MMSE （ P 〉 0.05） and MOCA （P 〉0.05 ） in the control group were not any statistically different among various time points of observation. Conclusion Type 2 diabetes mellitus will aggravate cognitive dysfunctions of stroke patients, which started to recover in 6 months of onset of the stroke.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2008年第10期697-699,共3页
Chinese Journal of Physical Medicine and Rehabilitation
基金
上海市科学技术发展基金（044119736）
关键词
2型糖尿病
脑卒中
认知功能
Type 2 diabetes mellitus
Stroke
Cognitive function
