摘要
本文采用生物活性测定法检测了３１例脑囊虫病患者外周血单个核细胞（ＰＢＭＣ）体外诱生ＩＬ－２、ＩＦＮ－γ及ＴＮＦ－α活性，以３０例正常人作对照，探讨了脑囊虫病人细胞因子的变化及在免疫调节中的作用。结果显示：脑囊虫病患者ＰＢＭＣ体外诱生的ＩＬ－２、ＩＦＮ－γ水平明显降低，与正常人相比差异显著（Ｐ＜０．０５，Ｐ＜０．０１），而患者ＰＢＭＣ体外诱生的ＴＮＦ－α水平明显高于正常对照组（Ｐ＜０．０１）；提示脑囊虫病患者的ＣＤ＋４Ｔｈ１细胞呈低应答状态，脑囊虫病患者过量产生的ＴＮＦ－α可能是造成脑囊虫病的免疫病理损害原因之一。
o investigate the levels of cytokines in peripheral blood mononuclear cells (PBMC) from patients with cerebral cysticercosis,We assayed IL2、IFNγ and TNFα production in PBMC in vitro from 31 patients with cerebral cysticercosis and 30 healthy controls with bioassay methods.The results showed that IL2 and IFNγ production in culture supernatants from PBMC in patient group was significantly lower than that in control group,but TNFα production in culture supernatants from PBMC in patient group was significantly higher than that of control group.These results suggested that the responsiveness of CD+4Th1 is much suppressed in patients with cerebral cysticercosis as evidenced by decreased IL2 and IFNγ induced from PBMC,while a high level of TNFα induced in vitro from PBMC of patients with cerebral cysticercosis may be one of the reasons leading to immunopathological damages of patient.
出处
《寄生虫与医学昆虫学报》
CAS
1997年第4期207-210,共4页
Acta Parasitologica et Medica Entomologica Sinica
