摘要
目的探讨一期病灶清除载药磷酸钙人工骨(CPC)充填治疗慢性骨髓炎的临床疗效。方法22例慢性骨髓炎患者行彻底清创后,一期植入载药CPC。结果22例获随访(26.3±6.5)个月,患者术后均未出现过敏或毒性反应,无皮疹或高热;随访期间均无骨髓炎复发,未见明显的全身反应,无再骨折;X线片显示植入CPC与宿主骨接触紧密,界面处未见间隙存在,骨缺损处的解剖形状完全或大部分恢复,未见脱落现象,随访期内18例患者CPC部分降解成骨。结论在病灶清除后,载药CPC一期充填残留的感染性骨缺损治疗慢性骨髓炎可有效控制感染。
Objective To study the clinical effect of one-stage antibiotic loaded calcium phosphate cement （CPC） for reconstructing bone defect from debridement of chronic osteomyelitis. Methods 22 patients with chronic osteomyelitis were treated with one-stage antibiotic loaded calcium phosphate cement after debridement. Results The 22 patients were followed up for （ 26. 3± 6. 5 ） months. Allergic and toxic reaction were not found in all patients. The radiological examination showed that the implanted CPC was directly bonded to the bone at the interface and the bone contour at the defect sites was successfully restored. Degeneration and new bone was formed in 18 patients. Conclusions Infection control can be attained in these patients with chronic osteomyelitis treated with one-stage antibiotic loaded calcium phosphate cement after debridement.
出处
《临床骨科杂志》
2008年第6期512-514,共3页
Journal of Clinical Orthopaedics
基金
义乌市科技攻关项目(编号:2006-G3-15)
关键词
载药磷酸钙人工骨
清创
骨髓炎
antibiotic loaded calcium phosphate cement
debridement
osteomyelitis
