摘要
用青霉胺和氨甲蝶呤联合治疗类风湿关节炎33例,并与单用青霉胺治疗的59例患者比较,结果显示临床缓解、显效、有效和无效的发生率在联合治疗组分别为24.2％,51.6％,24.2％和0;及在青霉胺组分别为18.6％,39.1％,25.4％和16.9％,经Ridir分析P<0.05。副作用发生率在两组分别为21.2％和16.9％(P>0.05)。结果提示,联合治疗的疗效优于单一青霉胺治疗的效果。
Thirty-three patients with rheumatoid arthritis (RA) were treated with penicillamine (0.25g/d) and methotrexate (MTX, 7.5mg/w-10mg/w), and compared with 59 patients treated by penicillamine alone. The results showed that the rate of clinical remission, marked improvement, improvement and no change was 24% ,52%, 24% and 0 respectively in patients treated with penicillamine and MTX, 18.6%, 39.1%, 25.4% and 16.9% respectively in patients using penicillamine alone (P < 0.05). The drug side effects occured in 7(21.2%) patients from combined therapy group and 10(16.9%) patients from penicillamine group (P>0.05). It is considered that combination of penicillamine and MTX in the treatment of RA is more effective as compared with the results of using penicillamine alone.
