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平阳霉素治疗恶性胸腔积液的临床观察

Preliminary clinical observation of pingyangmycin in treatment of malignant pleural effusion
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摘要 目的观察平阳霉素治疗恶性胸腔积液的疗效。方法经病理或细胞学证实的恶性胸水患者168例,尽量抽尽胸水后胸腔内注入平阳霉素40 mg/m^2+生理盐水20 ml,视胸水多少,5-7 d后再重复治疗。结果恶性胸水患者168例,CR 81例(48.2%),PR 47例(28.0%),NC 40例(23.8%),总有效率为76.2%。结论平阳霉素是治疗恶性胸腔积液的有效药物之一。 Objective To evaluate the efficacy of pingyangmycin(PYM) in trentment of malignant pleural effusion. Methods 168 patients with malignant pleural effusion were diagnosed by cytology or pathology. 40mg/m^2 of PYM was injected into pleural cavity after the effusion was drained up. The treatment could be repeated 5 - 7 days later according to the amount of the effusion. Results 168 patients with pleural effusion showed CR 81 eases(48.2% ) ,PR 47 cases(28.0% ) ,NC 40 cases(23.8% ), with the total response rate of 76.2%. Conclusion PYM is one of effective drugs for treatments of malignant pleural effusion.
作者 仵红雷
出处 《中国肿瘤临床与康复》 2008年第5期451-452,共2页 Chinese Journal of Clinical Oncology and Rehabilitation
关键词 平阳霉素 胸腔积液 恶性 Pingyangmycin Pleural effusion, malignant
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参考文献3

  • 1Millar JW, Hunfer AM, Home NW. Intrapleural immunotherapy with Corynebaeterium parvum in recurrent malignant pleural effusions[J]. Thorax,1980,35( 11 ) :856.
  • 2Sartori S, Tassinari D, Ceccotti P, et al. Prospective randomized trial of intrapleural bleomycin versus interferon alfa-2b via ultrasound-guided small-bore chest tube in the palliative treatment of malignant pleural effusions [ J ]. J Clin Oncol, 2004, 22 ( 7 ) : 1228-1233.
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