摘要
目的:观察冠状动脉内支架置入术后血清IL-6与TNF-α水平的变化及黄芪注射液的干预作用。方法:选冠状动脉内支架置入术患者60例,随机分为常规治疗组和黄芪治疗组,黄芪治疗组在常规治疗组的基础上予以黄芪注射液20mL,加入生理盐水250mL中静脉滴注,1次/d,疗程14d;两组取支架置入前和术后24h及2周后肘静脉血,行血清IL-6与TNF-α检测,另设30例正常对照组,空腹采血做血清IL-6与TNF-α检测。结果:冠心病患者血清IL-6和TNF-α较非冠心病患者明显升高(P<0.05);支架置入术后24h血清IL-6和TNF-α显著增高(P<0.05);支架置入术后14d两组患者IL-6和TNF-α均有不同程度下降,黄芪治疗组下降更显著。结论:IL-6和TNF-α是反映支架置入术后早期炎性反应的敏感指标,黄芪注射液可明显降低老年冠心病支架置入术后血清IL-6和TNF-α含量。
Objective To investigate the changes of the serum levels of IL-6 and TNF-α as well as their significance after coronary artery stent implantation in elderly patients and effect of intervention by astragalus mongholicus injection. Methods The study involved 60 patients who underwent coronary artery stent implantation and 30 patients who were normal. Blood samples were taken from the vein before 24 hours and after successful coronary stenting and 2 weeks after treatment with astragalus mongholicus injection. Serum concentrations of IL-6 and TNF-α were measured. Results The serum levels of IL-6 and TNF-α were higher in the patients with coronary heart disease than the normal（P〈0.05）. The concentrations of IL-6 and TNF-α were significantly higher after 24 hours of stent- implantion（P%0.05）. After treatment, the concentrations of IL-6 and TNF-α were lower than before treatment. The concentrations of IL-6 and TNF-α in patients treated with astragalus mongholicus injection were significantly lower than the conventional therapy. Conclusion IL-6 and TNF-α are sensitive resembles of the early inflammatory response after coronary stent implanation. Astragalus mongholicus injection can obviously decrease the serum IL-6 and TNF-α levels in patients after coronary stent implanation.
出处
《中华实用诊断与治疗杂志》
2008年第11期832-834,共3页
Journal of Chinese Practical Diagnosis and Therapy
关键词
冠心病
支架
黄芪注射液
IL-6
TNF-Α
Coronary heart disease
stent
astragalus mongholicus injection
IL-6
TNF-α
