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一氧化氮和内质网应激 被引量：5

Nitric oxide and endoplasmic reticulum stress
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摘要 Nitric oxide (NO) is a multifunctional biomolecule involved in a variety of physiological and pathological processes, including regulation of blood vessel dilatation and function as a neurotransmitter. However, a large amount of NO is toxic to the host and causes several diseases such as cardiovascular system diseases, septic shock, and diabetes mellitus. Endoplasmic reticulum (ER) stress pathway was first identified as a cellular response pathway induced by the accumulation of unfolded proteins in ER to preserve ER functions. Later it was found that ER stress pathway is also activated by various cellular stresses to protect cells, but when stresses are severe, apoptosis is induced to remove damaged cells. It is reported that NO disturbs ER functions, then ER stress-mediated apoptosis pathway is activated. CHOP/GADD153, which belongs to C/EBP transcription factor family, is induced in this process and mediates apoptosis. ER stress pathway induced by NO is involved in the pathogenesis of various diseases. Nitric oxide （NO） is a multifunctional biomolecule involved in a variety of physiological and pathological processes, including regulation of blood vessel dilatation and function as a neurotransmitter. However, a large amount of NO is toxic to the host and causes several diseases such as cardiovascular system diseases, septic shock, and diabetes mellitus. Endoplasmic reticulum （ER） stress pathway was first identified as a cellular response pathway induced by the accumulation of unfolded proteins in ER to preserve ER functions. Later it was found that ER stress pathway is also activated by various cellular stresses to protect cells, but when stresses are severe, apoptosis is induced to remove damaged cells. It is reported that NO disturbs ER functions, then ER stress - mediated apoptosis pathway is activated. CHOP/GADD153, which belongs to C/EBP transcription factor family, is induced in this process and mediates apoptosis. ER stress pathway induced by NO is involved in the Dathogenesis of various diseases.
作者 陈静 秦炯 韩颖 刘晓燕
机构地区 北京大学第一医院儿科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2008年第11期2272-2275,共4页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目(No.30571969) 北京市自然科学基金资助项目(No.7063096) 教育部高校博士点基金资助项目(No.20040001114)
关键词 细胞凋亡 钙 内质网 一氧化氮 Apoptosis Calcium Endoplamic reticulum Nitric oxide
分类号 R363 [医药卫生—病理学]
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参考文献35

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共引文献7

同被引文献47

  • 1于冬青,邓华聪,刘金波.辛伐他汀对糖尿病大鼠肾脏氧化应激的抑制作用[J].中国病理生理杂志,2006,22(4):824-825. 被引量：12
  • 2王剑,邱建华.一氧化氮和心钠素对耳蜗血流的影响[J].中华耳科学杂志,2006,4(3):234-237. 被引量：3
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引证文献5

二级引证文献38

中国病理生理杂志
2008年 第11期

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