摘要
目的:观察高容量血液滤过(HVHF)辅助治疗急性呼吸窘迫综合征(ARDS)的临床疗效。方法:18例ARDS患者随机分为HVHF组和连续性血液滤过组(CVVH组),两组在给予机械通气、抗感染及对症支持治疗的基础上,HVHF组9例患者辅以HVHF,CVVH组9例患者行CVVH,观察两组预后、治疗前后氧合指数(OI)的变化及第1天治疗前后炎症介质(TNF-α、IL-6、IL-8、IL-10)的变化。结果:HVHF组死亡3例,CVVH组死亡7例。两组氧合指数(OI)比较在第2天和第3天均有显著性差异(P<0.05),但以HVHF组更为显著(P<0.05);两组均能显著降低炎症介质(TNF-α、IL-6、IL-8)的浓度(P<0.01),以HVHF组更为显著(P<0.01),且HVHF组还能显著降低IL-10的浓度(P<0.01)。结论:HVHF辅助治疗ARDS是有效的一种方式。
Objective：To observe the therapeutic effect of high-volume hemofiltration（HVHF）used as the assistant treatment for acute respiratory distress syndrome（ARDS）.Methods：The 18 ARDS patients were randomized into HVHF group and Continuous Venovenous Hemofiltration（CVVH） group.Both groups were given mechanical ventilation,anti-infection and heteropathy,and HVHF was applied to the 9 patients of HVHF group and CVVH applied to the 9 patients of CVVH group.The prognosis of two groups,the changes of oxygenation index（OI）before and after treatment,and the changes of inflammatory mediums TNF-α,IL-6,IL-8 and IL-10 one day before and after treatment were observed.Results：In the HVHF group,3 patients died,and in the CVVH group,7 patients died.The OI comqarison of two groups on the 2nd and 3rd days showed a significant difference（P〈0.05）,but the difference in HVHF group was more obvious（P〈0.05）.The TNF-α,IL-6 and IL-8 of two groups decreased in concentration significantly（P〈0.01）,but the decrease in HVHF group was more obvious（P〈0.01）,and the concentration of IL-10 of HVHF group decreased significantly as well（P〈0.01）.Conclusion：HVHF is an effective assistant treatment for ARDS.
出处
《世界中西医结合杂志》
2007年第12期716-718,共3页
World Journal of Integrated Traditional and Western Medicine
基金
江苏省卫生厅基金资助项目(NoZ200716)
关键词
高容量血液滤过
急性呼吸窘迫综合征
氧合指数
炎症介质
High-volume hemofiltration
Acute respiratory distress syndrome
Oxygenation index（OI）
Inflammatory medium
