摘要
目的:研究姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素在不同pH缓冲溶液中的稳定性。方法:以一定pH的缓冲溶液为反应介质,将姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素定量加入到反应介质中,高效液相色谱法测定姜黄素类化合物浓度的变化,采用动力学方法建立姜黄素类化合物降解速率方程。结果:在相同的条件下姜黄素类化合物的稳定性依次为:双去甲氧基姜黄素≥去甲氧基姜黄素≥姜黄素。结论:去甲氧基姜黄素对姜黄素产生稳定作用最强,为姜黄素的天然稳定剂。
Objective： To investigate the stability of cureumin, demethoxycurcumin and bisdemethoxycurcumin in different buffer solution. Method： To determine concentration of curcumin by HPLC when added curcumin, demethoxycurcumin and bisdemethoxycurcumin into the buffer solution the equation of degradation was established. Result： The sequence of stability are bisdemethoxycurcumin ≥ demethoxycurcumin ≥curcumin at the same condition. Conclusion： The demethoxycurcumin can stabilize curcumin more strong than the others. The demethoxycurcumin is a nature stabilizing agent for curcumin.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2008年第22期2611-2614,共4页
China Journal of Chinese Materia Medica
