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抗菌肽耐药性研究进展 被引量:11

Mechanism of Antimicrobial Peptide Resistance
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摘要 抗菌肽是生物体产生的一类具有抵抗外源性病原体功能的小分子多肽,具有抗细菌、真菌、病毒、癌细胞等多种活性。近几年的研究发现细菌会对抗菌肽产生耐药性。本文就细菌的构成性耐药性机制和诱导性耐药性机制等研究进展进行综述。 Antimicrobial peptides are a class of small peptides with anti-extrogenous pathogen activities.They are derived from organism and possess antibacterial,antifungus,antiviruses and anticancer cell actions.In recent years,it’s found that some microbial pathogens are able to resist antimicrobial peptides.The constitutive and inducible mechanism of a pathogen resists a given peptide were reviewed in this paper.
出处 《微生物学通报》 CAS CSCD 北大核心 2008年第11期1786-1790,共5页 Microbiology China
基金 江西省星火计划资助项目(No.200638)
关键词 抗菌肽 构成机制 诱导机制 耐药性 Antimicrobial peptides,Constitutive mechanism,Inducible mechanism,Resistance
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参考文献26

  • 1Kraus D. Peschel A. Molecular mechanisms of bacterial resistance to antimicrobial peptides. Curr Top Microbiol Immunol, 2006, 306: 231-250.
  • 2Riley MA, Wertz JE. Bacteriocin diversity: ecological and evolutionary perspectives. Biochimie, 2002, 84(5-6): 357-364.
  • 3Leippe M, Herbst R. Ancient weapons for attack and defense: the pore-forming polypeptides of pathogenic enteric and free-living amoeboid protozoa. J Eukaryot Microbiol, 2004, 51(5): 516-521.
  • 4Lay FT, Anderson MA. Defensins--components of the innate immune system in plants. Curr Protein Pept Sci, 2005, 6(1): 85-101.
  • 5Peschel A, Otto M, Jack RW, et al. Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. J Biol Chem, 1999, 274(13): 8405-8410.
  • 6Yeaman MR, Yount NY. Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev, 2003, 55(1): 27-55.
  • 7Cashman KA, Bayer AS, Yeaman MR. Diversity and susceptibility to antibiotics and cationic peptides among Enterococcus faecalis or Enterococcus faecium isolates of diverse clinical or geographic origin. 98th Genreal Meeting for the American Society for Microbiology, May 17-21 Atlanta GA, 1998.
  • 8Bayer AS, Prasad R, Chandra J, et al. In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterationsin cytoplasmic membrane fluidity. Infect Immun, 2000, 68: 3548-3553.
  • 9Yeaman MR, Bayer AS, Koo SP, et al. Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action. J Clin Invest, 1998, 101(1): 178-187.
  • 10顾其胜,朱彬.海藻酸盐基生物医用材料[J].中国组织工程研究与临床康复,2007,11(26):5194-5198. 被引量:31

二级参考文献28

  • 1俞怡晨,姚炎庆,张亚琼,陆轶业,郭圣荣,范华骅.壳聚糖-海藻酸盐纳米粒子的制备及其对BSA的载药与释放特性[J].功能高分子学报,2005,18(4):598-601. 被引量:14
  • 2侯天勇,许建中.藻酸盐在构建组织工程骨应用研究中的进展[J].中华创伤杂志,2006,22(12):949-951. 被引量:6
  • 3陈代杰,金飞燕.生物高分子(第5卷)[M].北京:化学工业出版社,2004:181-210
  • 4陈代杰,罗敏玉.生物高分子(第6卷)[M].北京:化学工业出版社,2004:194-217
  • 5PatelS.功能性藻类辅料.国际医药配料商情,2006,6(3):26-27.
  • 6ASTM F2064-00 Standard Guide for Characterization and Testing of Alginates as Starting Materials Intended for use in Biomedical and Tissue-Engineered Medical Products Appliction
  • 7Tam SK,Dusseault J,Polizu S,et al.Physicochemical model of alginate-poly-L-lysine microcapsules defined at the micrometric/nanometric scale using ATR-FTIR,XPS,and ToF-SIMS.Biomaterials 2005;26(34):6950-6961
  • 8Bunger CM,Gerlach C,Freier T,et al.Biocompatibility and surface structure of chemically modified immunoisolating alginate-PLL capsules.J Biomed Mater Res A 2003;67(4):1219-1227
  • 9Robitaille R,Dusseault J,Henley N,et al.Inflammatory response to peritoneal implantation of alginate-poly-L-lysine microcapsules.Biomaterials 2005;26(19):4119-4127
  • 10Orive G,Tam SK,Pedraz JL,et al.Biocompatibility of alginate-poly-L-lysine microcapsules for call therapy.Biomaterials 2006;27(20):3691-3700

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