摘要
本文通过结扎大鼠部分阑尾，缝合相邻的肠管制备阑尾脓肿大鼠模型。该模型为更接近临床的阑尾脓肿血瘀模型，且操作简便，成功率高，重复性好。实验观察了活血化瘀药的治疗作用及治疗机制，结果表明，活血化瘀药能使阑尾脓肿大鼠白细胞吞噬功能明显提高，吞噬百分率给药组（５３．３８±６．０７％）较对照组明显升高（Ｐ＜０．０１），吞噬指数（２．３６±０．２６）较对照组显著升高（Ｐ＜０．０５）；能使阑尾脓肿明显缩小（Ｐ＜０．０１），给药１２天脓肿已形成包块。活血化瘀药能减轻炎细胞浸润，促进血管和纤维组织增生，加快向慢性炎症的转化。
We prepared the Periappendicular abscess rat model with the method of appendicular partial ligation and perippendicular suturing.The percent of phagocytosis of WBC was increased significantly in the rat model group treated with Huoxue Huayu herbs ( P <0.01).The degree of inflammatory cells infiltration was reduced and blood vessel and fiberoblast proliferation was promoted after 12 days of treatment with Huoxue Huayu herbs.
出处
《中国中西医结合外科杂志》
CAS
1997年第4期270-272,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
阑尾脓肿
活血化瘀
疾病模型
periappendicular abscess,Huoxue Huayu,WBC phagocytosis
