摘要
目的探讨肥胖型原发性高血压青年患者肱动脉内皮功能及颈动脉内中膜厚度的变化。方法通过应用高分辨率超声对40例肥胖型原发性高血压青年,30例血压正常肥胖青年及35例正常对照组,测量血流介导的肱动脉内皮依赖性舒张功能(FMD)及颈动脉内中膜厚度(IMT)。结果肥胖型原发性高血压青年组及血压正常肥胖青年组FMD明显低于正常对照组(P<0.05);肥胖型原发性高血压青年组IMT与对照组比较差异有统计学意义(P<0.05)。结论青年人肥胖和原发性高血压与血管内皮功能及颈动脉内中厚度关系密切。
Objective To investigate on relationship between vascular endothelium function and the carotid intima-media thickness （IMTc） in young obese people with essential hypertension. Method The brachial artery flow-madiated vasodiletiou（FMD） and IMTc were detected by high resolution ultrasound technique in 40 young obese patient with essential hypertension, 30 young obese with non-hypertension and 35 young healthy subjects. Results FMD was significantly reduced in obese young patients with essential hypertension and young obese patients with non-hypertension （P 〈 0.05 ） ; IMTc was significantly increased in young obese patient with essential hypertension （ P 〈 0.05）. Conclusion Obesity and hypertension might be closely correlated with decreased vascular endothelium function and increased IMTc in obese young people.
出处
《内科》
2008年第6期833-835,共3页
Internal Medicine
基金
广西壮族自治区卫生厅自筹经费科研课题(NO.Z2006092)
关键词
肥胖
青年
高血压
内皮功能
颈动脉内-中膜厚度
Obesity
Youth
Essential hypertension
Endothelium function
Carotid intima-media thickness
