摘要
对288例肌注林可霉素患者的局部ADR进行集中监测,19例出现ADR,发生率为6.6％。四种肌注林可霉素给药方案的ADR发生率为:(1)年龄≥14岁组:方案Ⅰ:0.6g/次,(30％—2mL/次)共101例,发生率14.8％;方案Ⅱ:0.6g/次(10％—6mL或12％—5mL/次)52例,发生率1.9％;(2)年龄<14岁组:方案Ⅲ:10mg/(kg·次),90例,发生率0％;方案Ⅳ:15mg/(kg·次),45例,发生率6.7％。19例ADR表现为红、肿、热、痛局部反应。19例ADR平均程度分、出现时间及持续时间分别为4.4±1.8分,2.2±0.7d及4.1±2.1d。
Local adverse drug reactions of injection of lincomycin were monitored in 288 patients who received intramuscular injection of lincomycin. 19 patients developed adverse drug reactions with rate being 6.6%. The results in terms of ADR rates of different intramuscular injection regimens are as follows; 1) In age >14y group, rate for regiment I was 14-8% (0. 6g/time, 30% - 2ml/time, n=101) and rate for regimen r was 1.9% (0.6g/time, 10% -6ml or 12% -5ml/time, n = 52)i 2) In age <14 group, rate for regimen I was 0% (10mg/kg - time, n = 90) and rate for regimen IV was 6.7% (15mg/kg - time, n = 90). The adverse drug reactions were manifested by local reactions such as redness, swelling, hot feeling and pain. The average scores of ADRs, onset time, and duration were 4.4 + 1.8, 2-2 ± 0.7 days and 4.1 ± 2.1 days.
出处
《药物流行病学杂志》
CAS
1997年第2期70-74,共5页
Chinese Journal of Pharmacoepidemiology
基金
国家自然科学基金资助
关键词
林可霉素
ADR监测
局部反应
肌注
Lincomycin
ADR monitoring
Local reaction
Muscular injection
