摘要
目的探讨经直肠超声结合前列腺特异性抗原密度（PSAD）与移行区校正的前列腺特异性抗原密度（PSATZ）对前列腺癌的诊断价值。方法选取经病理证实的前列腺癌（PCa）与良性前列腺增生（BPH）患者各19例,就其声像图特征、前列腺特异性抗原（PSA）及其相应的PSAD和PSATZ进行分析比较。结果19例PCa中,超声发现14例,5例仅提示为BPH。14例中,1例为弥漫性病变,13例为结节性病变。共检出16个结节,其中低回声结节占75%（12/16）,高回声及混合回声占25%（4/16）;13个结节位于外周区,3个位于移行区。PCa的PSA值为8.61-98.65ng/ml,平均（48.79±25.34）ng/ml;BPH的PSA值为0.58-28.36ng/ml平均（9.73±8.19）ng/ml。PCa与BPH两组间的前列腺体积及其移行区体积比较,差异无统计学意义（P〉0.05）;而PSAD与PSATZ则PCa组显著高于BPH组,差异有高度统计学意义（P〈0.01）。结论经直肠超声对PCa诊断的敏感性较高,特异性较低,结合PSAD及PSATZ则可提高对PCa的检出率。
Objective To discuss the value of transrectal ultrasound （TRUS） and prostate specific antigen density （PSAD） and prostate specific antigen density of transition zone （PSATZ） for diagnosing prostate cancer. Methods Chose cases of prostate cancer（PCa） and benign prostate hyperplasia（BPH） , each was 19 ,all the cases were authenticated by pathology .Then compared the characteristic of prostate cancer with prostate specific antigen（PSA） and homologous PSAD, PSATZ. Results Fourteen cases were discovered by ultrasound among the 19 PCa, the others were only diagnosed as BPH.Among the 14 cases, diffuse pathological changing was found in 1 patient, nodular changing in 13 patients （16 nodules were found）. Among the 16 nodules, there were 13 hypoechoic nodules （75%） and 3 hyper echoic or compound echoic nodules （25%）, and there were 13 nodules in outer zone and 3 nodules in transition zone.The PSA of PCa and BPH was 8.61-98.65 ng/ml [（48.79±25.34）ng/ml] and 0.58-28.36 ng/ml [（9.73±8.19）ng/ml]. There were no significant differences between the volume of prostate and prostate transition zone （P〉0.05）, but there were significant differences between the PSAD and PSATZ （P〈0.01）, That the PCa group was higher than that in the BPH group. Conclusion It is higher sensitive but bess specific in diagonosis PCa by means of transrectal ultrasound. If it is combined with PSAD and PSATZ, the diagnostic rate of PCa is highly raised.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2008年第5期811-813,共3页
Suzhou University Journal of Medical Science
基金
苏州市科技局资助项目(SSY0621)
关键词
经直肠超声
前列腺癌
前列腺特异性抗原
transrectal ultrasound
prostate cancer
prostate specific antigen
