摘要
目的通过对66例幽门螺杆菌感染(HP)者临床分离菌株的培养和药敏试验,分析幽门螺杆菌对常用抗生素的耐药性,为临床选用抗生素治疗HP提供依据。方法采用Kiby-bauer法检测HP临床分离菌株对阿莫西林、甲硝唑、克拉霉素、左氧氟沙星、四环素、呋喃唑酮的耐药率,并分析性别、年龄及不同疾病对耐药率的影响。结果幽门螺杆菌对阿莫西林、甲硝唑、克拉霉素、左氧氟沙星、四环素、呋喃唑酮的耐药率分别为4.0%、32.0%、10.0%、24.0%和6.0%、0%;甲硝唑在女性与男性中的耐药率存在差异(P<0.05)。不同年龄和不同临床疾病患者,HP对各抗生素耐药率比较无显著性差异(P>0.05)。结论本地区幽门螺杆菌对呋喃唑酮、阿莫西林、四环素、克拉霉素的敏感性较高,对甲硝唑、左氧氟沙星的耐药耐药性较高;女性甲硝唑耐药高于男性,各抗生素耐药与患者年龄和疾病种类无关。
Objective To analyze the antibiotic resistance of Helicobacter pylori （HP）by cultivation and drug sensitive test of clinical isolated strains in Liaocheng. Methods To observe antimicrobial susceptibility of HP strains to Amoxicilin, Metronidazole, Clarithromycin, levofloxacin, tetracycline and furazolidone by Kirby-Bauer disk diffusion test. Results The percentage of resistant strains were as follows ：4.0% to amoxicillin,32.0% to metronidazole,10.0% to clarithromycin,24.0% to levofloxacin,6.0% to tetracycline and 0% to furazolidone ;Resistance of HP to metronidazole was different between man and woman（ P 〈 0.05 ）. Resistance to each agent was the same in different age and stomach diseases（ P 〉 0.05 ）. Conclusion Susceptibility of HP to furazolidone, amoxicillin, Tetracycline and clarithromycin are high. However, resistance to metronidazole and levofloxacin are high;Resistance of HP to Metronidazole is higher in woman than that in man. There are no relationships between resistance and different age and stomach diseases.
出处
《临床内科杂志》
CAS
2008年第11期747-749,共3页
Journal of Clinical Internal Medicine
关键词
幽门螺杆菌
抗生素
耐药性
Helicobacter pylori
Antibiotic
Resistance
