摘要
目的:探讨磷酸化信号转导及转录活化因子3(phospho-tyr05-STAT3)和ki67在卵巢上皮性肿瘤中发生发展的作用及相互关系。方法:采用免疫组化SP法检测38例恶性卵巢上皮性肿瘤组织(恶性组)、30例良性卵巢上皮性肿瘤组织(良性组)和16例正常卵巢组织(正常组)中p-STAT3和ki67的表达。结果:恶性组中p-STAT3的阳性表达率84.21%(32/38)显著高于良性组32.22(9/30)和正常组巢组织18.12(3/16);ki67在恶性组阳性表达率显著高于良性组和正常组,分别为78.95(30/38)、32.22(9/30)和12.20(2/16)。p-STAT3表达与临床分期、淋巴转移和病理分级相关(P<0.05),与患者年龄和病理类型无关,并且与ki67表达呈正相关(p<0.05)。结论:p-STAT3的异常活化可促进恶性卵巢肿瘤细胞的过度增殖,ki67较好的反应了癌细胞的增殖状态,二者结合检测对恶性卵巢肿瘤的临床诊断和治疗有一定价值。
Objective： To investigate roles of phospho-Tyr705-STAT3 （p-STAT3） and Ki67 in tumorigenesis of the epithelia ovarian cancer and the relationship between p-STAT3 and the tumor cell＇ s proliferation, which is measured by the proliferation marker Ki67. Methods： The expressions of p-STAT3 and Ki67 were examined by immunohistochemicstry. Results： The positive rate of p-STAT3 in ovarian cancer （84.21% ,32/38） was significantly higher than ovarian benign tumor （32.22% ,9/30） and normal ovarian tissue （18.12,3/16）. The positive rate of Ki67 in ovarian cancer was significantly higher than ovarian benign tumorand normal ovarian group. The p-STAT3 expression was associated with histological grades and clinical stages （ P 〈 0.05 ） , and positively correlated to Ki67 expression （ P 〈0.01 ）. Conclusion ： Abnormal activation of STAT3, resulted in pro-liferation of tumor cells, is involved inovarian tumorigenesis. Ki67 is a favorable marker of proliferation of ovarian tumor cells, and may provide useful information for diagnosis.
出处
《河南医学研究》
CAS
2008年第3期210-212,217,共4页
Henan Medical Research
