摘要
目的评价多种影像学检查方法在兔肝VX2移植瘤经门静脉阻断后显示肝动脉与门静脉血供改变中的作用。材料与方法40只新西兰大白兔随机分为门静脉阻断后即刻移植瘤体组(实验A组)、移植瘤体生长3周后门静脉阻断组(实验B组)、阴性对照C组、移植瘤体未行门静脉阻断的阳性对照D组各10只,分别行兔肝动脉与门静脉的MSCTA、DSA及钡剂血管灌注检查。结果肝动脉的DSA检查成功率为85%,明显低于MSCTA检查(100%)(P<0.05),但肝动脉和门静脉的其他检查方法成功率无明显差异(P>0.05)。经MSCTA检查对Ⅲ级以上肝动脉分支的显示率(40%)明显低于Ⅰ、Ⅱ级肝动脉分支的显示率(分别为100%和70%)(P<0.05),同样也明显低于DSA和血管灌注的Ⅲ级以上肝动脉分支的显示率(分别为88.24%和75.77%)(P<0.01)。在门静脉各级分支的显示方面,MSCTA、DSA和血管灌注均无显著性差异(P>0.05)。结论MSCTA可无创直观地显示兔肝动脉与门静脉的空间解剖细节,在兔肝门静脉阻断效果的评价中起着重要作用。
Objective To evaluate the value of multiple imaging examinations of the hepatic vascular anatomy,and the efficacy of blood supply change after portal vein occlusion in rabbits with hepatic VX2 tumor. Materials and Methods 40 New Zealand white rabbits were randomly divided into four groups in 10 each group,including test group A,test group B, negative control group C and positive control group D. To the experimental rabbits in the group A, portal branch ligation（PBL） of the left external branch of portal vein was carried out at the time of implantation of the VX2 tumor tissue into the left external lobe. To the test group B, portal vein PBL of the left external branch was performed after 3 weeks of the tumor implantation of the left external lobe. 2 weeks later, multislice CT angiography （ MSCTA）, DSA and vascular perfusion were performed respectively on these rabbits. Results The success rate of hepatic arterial examination by DSA was significantly lower than that by MSCTA（ 85% versus 100% ,P 〈 0.05 ）, but there was no statistical difference in the other examinations of hepatic artery and portal vein. The total displaying rate of the branch ≥Ⅲ of hepatic artery by MSCTA （ 40% ） was also significantly lower than that of Ⅰ and Ⅱ branches of hepatic artery（ 100% and 70% , respectively） （P 〈 0.05 ） , and was significantly lower than that by DSA and the vascular perfusion （88.24% and 75.77% , respectively） （P 〈 0.01 ）. However, there was no statistical difference to the displaying rate of portal vein between MSCTA, DSA and the vascular perfusion（ P〈0.05 ）. Conclusion MSCTA can clearly display spacial details of the hepatic vascular anatomy in rabbits. As a noninvasive method, MSCTA plays an important role to evaluate the efficacy of blood supply change after portal vein occlusion in rabbits with hepatic VX2 tumor.
出处
《临床放射学杂志》
CSCD
北大核心
2008年第11期1579-1584,共6页
Journal of Clinical Radiology
