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乳腺癌中survivin的表达与血管生成的关系 被引量:4

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摘要 目的探讨survivin表达与乳腺癌血管生成的关系。方法应用免疫组化法(IHC)检测survivin在40例乳腺癌组织、10例癌旁正常腺体组织中的表达情况;以FⅧ-RA作为血管内皮标记物,计数乳腺癌组织微血管密度(MVD)的表达情况。结果survivin在乳腺癌组织中的阳性表达率为62.5%(25/40),而10例癌旁腺体组织中无表达,两者差异有统计学意义(P<0.05)。40例乳腺癌组织中的MVD为(43.73±10.07)个/HP,其中25例survivin阳性组中MVD的表达为(63.33±10.36)个/HP,显著高于15例阴性组的(20.12±8.47)个/HP(P<0.05)。结论survivin的高表达可能参与乳腺癌中微血管的新生,故可作为评价乳腺癌生物学行为的指标之一。
出处 《中国普通外科杂志》 CAS CSCD 2008年第11期1137-1139,共3页 China Journal of General Surgery
基金 国家自然科学基金资助项目(30672420) 黑龙江省科技厅攻关项目(GB05C402-01) 黑龙江省哈尔滨医科大学附属二院青年基金资助(编号:QN2008-12)
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参考文献14

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