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雌激素对卵巢切除大鼠肾脏VDR mRNA表达的影响 被引量:3

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摘要 目的探讨雌激素对卵巢切除(OVX)大鼠肾脏维生素D受体(VDR)mRNA表达的影响。方法25只成年雌性SD大鼠随机分为为假手术组、OVX组、OVX+补充雌激素组、OVX+补充孕激素组和OVX+补充雌、孕激素组(n=5)。于分组处理2月后处死大鼠取肾脏组织,RT-PCR检测各组VDR mRNA的相对表达量。结果OVX组大鼠肾脏VDRmRNA表达显著低于假手术组(P<0.05);与OVX组相比,OVX+补充雌激素组和OVX+补充雌、孕激素组大鼠肾脏VDR mRNA表达显著增加(P<0.05)。结论OVX大鼠肾脏组织VDR mRNA表达减少;雌激素能促进OVX大鼠肾脏组织VDR mRNA的表达。
出处 《上海交通大学学报(医学版)》 CAS CSCD 北大核心 2008年第11期1474-1475,共2页 Journal of Shanghai Jiao tong University:Medical Science
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