摘要
探讨Th1、Th2和Th17型细胞在类风湿性关节炎(RA)和系统性红斑狼疮(SLE)发病机制中的作用。收集37例RA患者、25例SLE患者和34例健康人的抗凝血,应用ELISA检测血清中IFN-γ、IL-10和IL-17的水平。与健康对照组比较,RA和SLE患者血清中IFN-γ的水平均具有统计学意义(P<0.05);SLE患者IL-10水平出现有意义的升高(P<0.05);而RA患者IL-17的升高具有统计学意义(P<0.05)。由此提示Th1、Th2和Th17细胞在自身免疫性疾病中均发挥不同的重要作用。
In order to evaluate the role of Th1, Th2, and Th17 cells in pathogenesis of rheumatoid arthritis （RA） and systemic lupus erythematosus （ SLE）, anticoagulant blood samples from 37 eases of RA patients, 25 eases of SLE patients and 34 eases healthy persons （normal control, NL） were collected to test their levels of IFN-γ, IL-10, and IL-17 in serum using sandwitch enzyme-linked immunosorbent assay （ELISA）. As compared with healthy persons （NL） the levels of IFN-7 in RA and SLE patients＇ serum have statistic significance （P 〈 0.05）, the level of IL-10 in SLE patients＇ serum raised significantly （P 〈 0.05 ）, and the levels of IL-17 in RA patients＇ serum have statistic significance （P 〈 0.05）. Therefrom indicated that Th1, Th2, and Th17 cells played different but important roles in autoimmunc diseases.
出处
《微生物学杂志》
CAS
CSCD
2008年第5期98-101,共4页
Journal of Microbiology
基金
辽宁省教育厅科学技术研究项目[2004(049)]
