摘要
目的比较氟康唑、特比萘芬及伊曲康唑对白念珠菌的体外敏感性。方法采用NCCLS公布的M27-A方案微量稀释法测定氟康唑、特比萘芬及伊曲康唑对22株临床分离的白念珠菌的体外敏感性。结果22株白念珠菌对氟康唑耐药9株,敏感12株;对伊曲康唑耐药7株,敏感8株;对特比萘芬耐药12株,敏感3株。结论3种药物中氟康唑的敏感性相对较高,但仍有耐药现象,氟康唑与伊曲康唑存在交叉耐药。
Objective To compare the susceptibility of Candida albieans cultured with Flueonazole,Terbinafine and Itraeonazole. Methods M27 - A microdilution method based on NCCLS was used to determined the susceptibility of 22 Candida albicans isolates cultured with Fluconazole , Terbinafine and Itraconazole. Results 9 Flueonazole-resistance isolates, 12 susceptible isolates, 7 Itraconazole-resistanee isolates ,8 susceptible isolates, 12 Terbinafine-resistance isolates and 3 susceptible isolates were detected from 22 clinical candida albicans isolates. Conclusion The susceptibility to Fluconazole of Candida albicans was the highest in the three drugs, but the resistance to Fluconazole and Itraconazole and cross-resistance between Fluconazole and Itraconazole were found in this study.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2008年第11期668-669,共2页
The Chinese Journal of Dermatovenereology
关键词
白念珠菌
氟康唑
特比萘芬
伊曲康唑
Caudida albicans
Flueonazole
Terbinafine
Itraconazole
