摘要
目的:探讨扶正清瘿方对自身免疫性甲状腺炎大鼠Treg细胞的影响。方法:复制实验性自身免疫性甲状腺炎(EAT)动物模型,分别给予扶正清瘿方、扶正方、清瘿方、地塞米松治疗,检测甲状腺淋巴细胞浸润分级指数、自身甲状腺抗体Tg-Ab、外周血T淋巴细胞CD4+、CD4+FoxP3+、CD4-FoxP3+细胞的变化。结果:扶正清瘿方较清瘿方和扶正方具有更好的调高T调节淋巴细胞的作用(P<0.05),地塞米松在各组中具有最佳的调高T调节淋巴细胞的作用(P<0.05),而清瘿方较扶正方具有更好的降低血清Tg-Ab抗体的作用(P<0.05)。扶正方组在甲状腺淋巴细胞浸润指数上较清瘿方为优(P<0.05),其作用与地塞米松相类似。结论:扶正清瘿方对自身免疫性甲状腺炎有较好的治疗效果,但不同配伍组方的作用各有所长,扶正方长于抑制细胞损伤,而清瘿方长于降低自身抗体。
Objective： To explore the effects of ＂Fuzheng Qingying Decoction＂ on T regulatory cell in the treatment of autoimmune disease. Methods： Experimental autoimmune thyroiditis （EAT） was modeled in rats and treated respectively with ＂Fuzheng Qingying Decoction＂, ＂Fuzheng Decoction＂, ＂Qingying Decoction＂ and dexameson. The thyroid lymphocyte index, Tg-Ab, CD4^＋, CD4^＋FoxP3^＋ and CD4^-FoxP3^＋ were detected. Results： ＂Fuzheng Qingying Decoction＂ and ＂Fuzheng Decoction＂ could upregulate T regulatory cell （P 〈 0.05）, and dexameson upregulated it most obviously （P〈 0.05）; ＂Fuzheng Qingying Decoction＂ decreased Tg-Ab more significantly than ＂Fuzheng Decoction＂ （P 〈 0.05） ;＂ Fuzheng Decoction＂ increased thyroid lymphocyte index more significantly than ＂Qingying Deeoction＂（P〈 0.05）, similar to dexameson. Conclusion： ＂Fuzheng Qingying Decoction＂ has good effects on autoimmune thyroiditis; while ＂Fuzheng Decoction＂ tends to prevent T regulatory cell and ＂Qingying Decoction＂ tends to decrease Tg-Ab.
出处
《上海中医药大学学报》
CAS
2008年第6期57-59,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市卫生局科研基金资助项目(03-4066)
