摘要
目的:探讨急性髓系白血病细胞中β-catenin和MMP-7表达的意义。方法:急性髓系白血病患者21例(病例组),非恶性血液病患者14例(对照组),采用免疫组织化学SP法测定骨髓单个核细胞(BMMNC)β-catenin和MMP-7的表达水平,记录免疫积分和表达阳性率。结果:病例组BMMNC中β-catenin和MMP-7的免疫积分分别为(88.17±36.58)和(74.79±35.39),阳性率分别为(50.75±34.78)%和(46.42±26.14)%,均高于对照组(P<0.05)。病例组β-catenin和MMP-7的免疫积分和阳性率均呈正相关关系(r分别为0.576,0.593,P均<0.05)。病例组伴有肝脾淋巴结肿大的患者β-catenin和MMP-7的免疫积分和阳性率均高于无肝脾淋巴结肿大者(P<0.05)。结论:急性髓系白血病细胞中β-catenin和MMP-7的表达呈正相关,2者与急性髓系白血病细胞髓外浸润有关。
Aim： To investigate the expressions of MMP-7 and β-catenin in acute myeloid leukemia（AML） cells.Methods：A total of 21 patients with AML and 14 patients without maligment hematological diseases（the control） were selected to detect the expressions of β-catenin and MMP-7 in BMMNC using immunohistochemical SP staining.Results： The expressions of MMP-7 and β-catenin in AML group were significantly higher than those of the control group（P〈0.05）.There was a positive correlation between the expressions of β-catenin and MMP-7 in AML group（P〈0.05）.The expressions of MMP-7 and β-catenin in AML patients with extramedullary infiltrations were significantly higher than those in patients without infiltration（P〈0.05）.Conclusion： The expression of MMP-7 was positively correlated with β-catenin in AML patients,and both of them may be involved in the extramedullary infiltrations of AML cells.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2008年第6期1213-1215,共3页
Journal of Zhengzhou University(Medical Sciences)
