摘要
目的：探讨ｐ５３基因表达异常的意义。方法：用免疫组织化学方法研究ｐ５３基因蛋白在胃癌中的表达。结果：７２例胃腺癌中３６例（５０．０％）阳性，高分化腺癌（５３．３％）和低分化腺癌（５８．６％）ｐ５３阳性率明显高于粘液癌（２３．１％），不同浸润深度的癌细胞与癌细胞ｐ５３阳性程度有关（Ｐ＜０．０５），在淋巴结转移组和无转移组间ｐ５３阳性率和阳性程度均无显著差异（Ｐ＞０．０５），病人的生存时间与ｐ５３阳性程度无明显的相关性（ｒ＝０．１８３，Ｐ＞０．０５），癌旁肠上皮化生和异型增生腺体全部为阴性。结论：ｐ５３异常表达是细胞癌变的标志之一。
Purpose To investigate the significance of abnormal expression of p53 in gastric cancer. Methods We detected the expression of p53 in gastric carcinoma by means of immunohistochemical technique. Results Positive staining of p53 was showed in 36(50 0%) among 72 cases of gastric carcinoma. The abnormal expression of p53 in well differentiated (53 3%) and poor differentiated adenocarcinoma (58 6%) were significantly higher than that in mucous adenocarcinoma (23 1%). The different extent of p53 positive staining was inspected in the cancer cells invased in various layer of stomach ( P <0 05). No significant difference of p53 expression was found between the patients with metastasted lymph nodes and those with non metastasted ones ( P >0 05). The relationship was not demonstrated between the p53 expression and the invival period of the patients ( r =0 183, P >0 05). The intestinal metaplasia and dysplasia glands around the carcinoma were all negative. Conclusions The abnormal expression of p53 is one of the indicators of canceration.
出处
《临床与实验病理学杂志》
CAS
CSCD
1997年第3期238-240,I020,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
免疫组织化学
胃肿瘤
P53基因
gastric carcinoma
immunohistochemistry
p53 protein
