摘要
目的:观察肠安颗粒对IBS模型大鼠体重及血清5-HT和NO含量变化的影响。方法:采用给予番泻叶煎剂和束缚应激致大鼠IBS模型,观察肠安颗粒对IBS模型大鼠体重以及大鼠血清5-HT和NO含量的影响,初步探讨IBS的发病机制。结果:肠安颗粒可明显改善由番泻叶引起的动物腹泻症状,使体重增长,与模型组比较有显著提高(P<0.05或P<0.01);并可明显提高血清中NO含量和5-HT含量,与空白对照组比较,差异显著(P<0.05或P<0.01)。组织学检查发现肠安颗粒高、中剂量组与模型组相比,均可明显改善炎性症状,改善粘膜上皮的形态,与空白对照组比较无明显病变。结论:肠安颗粒对IBS模型大鼠有一定的治疗复健作用,对肠黏膜有一定保护作用。
Objective ：To investigate the influences of Changan Granule on the model of rat with irritable bowel syndrome （IBS） by observing the weight, the content of Nitric Oxide （NO） and 5-hydroxytryptamine （5-HT） in serum of rat. Methods：The model of IBS rat was established by decoction of Folium Sennae and restraint stress, effects of Changan Granule were studied through observing the influences on rat weight and the content of NO and 5-HT in serum. Results：Compared to those of the model group, Changan Granule could improve diarrhea induced by Folium Sennae and increase body weight obviously （ P 〈 0. 05 or P 〈 0. 01 ）. Compared to the control group, Changan Granule could also increase the content of NO and 5-HT in serum significantly （ P 〈 0. 05 or P 〈 0.01 ）. Through histological survey, we discovered that the high and middle dose of Changan Granule could change the symptom of inflammation and improve the morphous of epithelium mucosae compared to the model group. And there were no obvious pathological changes on the high and middle dose groups of Changan Granule compared to the control group. Conclusion ： Changan Granule is effective to cure IBS and has protective effects on the bowel mucosae.
出处
《中药材》
CAS
CSCD
北大核心
2008年第11期1699-1702,共4页
Journal of Chinese Medicinal Materials
基金
上海市科委新药研究基金资助项目(04dz19820)
