摘要
白介素4受体（IL-4R）在支气管哮喘（简称哮喘）的发病机制中起重要作用，IL-4通过与IL-4R结合，刺激信号转导及转录激活因子6（STAT6）磷酸化构成二聚体由胞浆进入胞核，诱导Th2类细胞因子转录，导致哮喘症状。Q576R为1920位腺嘌呤A变成鸟嘌呤G，IL-4Rα链基因存在Q576R多态性，R576与儿童哮喘易感有关，可能是儿童哮喘易感的一个候选基因。IL-4Rα链576在IgE水平中发挥重要作用，R576与血浆总IgE水平相关性的讨论结果不一致。IL-4Rα链的其他基因多态性同样作用于哮喘，基因与基因的相互作用已经被关注。本文综述了IL-4Rα链Q576R基因多态性与哮喘关系的研究进展。
Interleukin-4 receptor（IL-4R） plays a key role in the development of bronchial asthma （asthma）. IL-4 connects with IL-4R, which in stimulates signal transducer and activator of transcription 6 （STAT6） phosphorylationed to be a dipolymer. This dipolymer goes to nucleolus from cytochylema which induces the transcription of the cytokine of helper T cell 2, leading the symptom of asthma. There is a Q576R polymorphism in IL-4Rα chain gene. R576 is related to the susceptivity of asthma,which may be a candidate gene of susceptivity of childhood asthma. IL-4R α chain 576 plays an important role in the serum IgE level. Reports about the relativity between R576 and the total serum IgE level are not the same. The polymorphisms of other genes are also related to asthma, the interaction between gene and gene has been concerned. This report summarizes the development of the relationship between asthma and polymorphisms of IL-4R α chain Q576R gene.
出处
《国际呼吸杂志》
2008年第21期1306-1309,共4页
International Journal of Respiration
基金
本课题为国家自然科学基金资助项目（编号30672268）
