摘要
目的研究环氧化酶-2(COX-2)、血管内皮生长因子(VEGF)在乳腺癌组织中的表达,并探讨其对血管生成的作用。方法应用免疫组织化学SP法检测30例乳腺癌组织标本和20例正常乳腺组织标本中COX-2、VEGF的表达,并用血管内皮细胞标记物CD34单克隆抗体标记行免疫组织化学染色,观察肿瘤微血管生成状况。结果COX-2在70.0%(21/30)乳腺癌组织中过表达,VEGF在56.7%(17/30)乳腺癌组织中过表达,与正常组织相比差异均有统计学意义;COX-2和VEGF表达相关;COX-2和VEGF表达均与肿瘤微血管生成相关。结论COX-2和VEGF过表达均与乳腺癌血管生成有关。
Objective To study the expressions of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor （VEGF） and their effects on tumor angiogenesis in human breast carcinoma. Methods The expressions of COX-2 and VEGF were detected in 30 cases of primary breast carcinoma and 20 samples of normal breast tissue by immunohistochemical method. The tumor micrangium was also examined using CD34 staining. Results The expression rate of COX-2 and VEGF in breast carcinoma tissue was 70.0% （21/30） and 56.7% （17/30）respectively, with significant difference compared with the nomal breast tissue. A significant correlation was found between COX-2 and VEGF expressions. Both COX-2 and VEGF were significantly correlated with tumor angiogenesis. Conclusion Both COX-2 and VEGF are related to tumor angiogenesis in breast cancer.
出处
《中华乳腺病杂志（电子版）》
CAS
2008年第6期33-36,共4页
Chinese Journal of Breast Disease(Electronic Edition)
关键词
乳腺肿瘤
环氧化酶-2
血管内皮生长因子
Breast carcinoma
Cyclooxygenase-2
Vascular endothelial growth factor
