摘要
目的:观察咪达唑仑联合氟芬合剂抑制内脏牵拉反射以及镇静、遗忘的临床效果。方法:选择14～68岁的硬膜外麻醉行下腹部手术病人80例,随机分为A、B两组,每组40例。A组为氟芬合剂组,采用芬太尼1μg.kg-1加氟哌利多0.05 mg.kg-1;B组为联合用药组,在A组基础上加咪达唑仑0.04 mg.kg-1。连续监测血压、脉搏、呼吸、血氧饱和度(SpO2),记录术中牵拉反射的程度和遗忘情况。结果:给药前后各组同时间点的血压、脉搏、呼吸、SpO2值无显著性差异,B组牵拉反射发生率均显著低于A组(P<0.05),B组较A组能产生较好的镇静、遗忘作用(P<0.05)。结论:咪达唑仑联合氟芬合剂可用作硬膜外麻醉的辅助药。
Objective ：To observe the sedative effect, amnesic extent and suppress to the pulling reaction of viscus of midazolam combinde with droperidol - fentanyl in the epidural anaesthseia. Methods： Eighty cases of expected epidural anaesthseia were randomly divided into 2 groups （n = 40 respectirely）. Group A was received droperidol - fentanyl, while group B was received midazolam combinde with droperidol - fentanyl. The HR, BP, R, Sp02 and sedative action were recorded indifferent period after the administration. The suppress to the pulling reaction of viscus were assessed by OAA/S. Results： There were no significant differences of HR, BP, R, SpO2 in the operation between two groups. The group B was with powerful sedative effect, deep amnesic extent and effective suppress to the pulling reaction of viscus compared with the group A （P 〈 0. 05 ）. Condusion： Midazolam combined with droperidol- fentanyl can be applied in the epidural anasethesia based on a strict operation management.
出处
《现代临床医学》
2008年第6期427-428,共2页
Journal of Modern Clinical Medicine
关键词
咪达唑仑
氟芬合剂
牵拉反射
镇静
遗忘
硬膜外麻醉
midazolam
droperidol - fentanyl
pulling reaction of viscu
sedative action
amnesic extent
epidural anaesthseia
