摘要
目的:观察灵芝三萜类化合物(GLT)对AD模型大鼠海马组织形态的影响。方法:70只大鼠随机分为生理盐水组,假手术组,模型组,溶媒组,GLT低、中、高剂量组;除生理盐水组和假手术组外,其余各组大鼠单侧海马内一次性注射Aβ25-35制作AD大鼠模型,术后生理盐水组、假手术组、模型组大鼠分别灌胃生理盐水,溶媒组灌胃食用油,GLT各组分别灌胃低、中、高剂量的GLT20d,然后采用透射电镜观察海马神经元的超微结构变化。结果:GLT能明显改善模型大鼠脑组织海马CA1区神经元的退行性变化。结论:GLT能改善大鼠海马CA1区神经元的退行性变化。
Objective： To observe the protective effects of triterpenoids from Ganoderma lucidum （GLT） on the modality of hippocampus tissue of Alzheimer disease （AD） model rats. Methods： AD rats induced by injection of Aβ25-35 into one side of hippocampus were treated with GLT orally for 20 days and then uhrastructural changes of neurons were observed under transmission electron microscope. Results： The modality of hippocampus CA1 region neurons of GLT treated AD rats was distinctly improved when compared with that of the model rats that did not receive GLT treatment. Conclusion： GLT can improve recessively changed neurons in hippocampus CA1 region.
出处
《贵阳医学院学报》
CAS
2008年第6期662-664,667,共4页
Journal of Guiyang Medical College
基金
贵州省科技攻关项目[D2004-4]
