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Bmi-1基因在结肠癌中的过度表达及其临床意义 被引量：5

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摘要 目的探讨结肠癌组织中Bmi-1基因mRNA表达与结肠癌分化、转移及临床预后的关系。方法收集我院2007年63例结肠癌手术的切除标本,提取肿瘤及癌旁组织配对标本的总RNA,用RT-PCR方法测定Bmi-1基因表达,并结合临床资料,对Bmi-1基因差异表达与结肠癌病人临床表现的相关性进行分析。结果63例配对标本分别进行Bmi-1 mRNA荧光检测比较,44例标本的肿瘤组织中Bmi-1基因mRNA表达明显高于癌旁正常结肠组织。Bmi-1 mRNA的表达与结肠癌大小、淋巴结转移和浸润深度密切相关(P<0.05),而与患者的性别、年龄、肿瘤分化程度等无关(P>0.05)。并且Bmi-1 mRNA阳性表达者生存率明显低于阴性者。结论Bmi-1在结肠癌组织表达状态与结肠癌的生长和浸润转移关系密切,可以作为反映结肠癌生物学行为的有效指标。
作者 徐丽姝
机构地区 广东省老年医学研究所消化科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2008年第22期2235-2237,共3页 Chinese Journal of Gerontology
关键词 结肠癌 BMI-1 基因表达 临床意义
分类号 R576 [医药卫生—消化系统]
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参考文献10

  • 1Haupt Y, Alexander WS, Barri G, et al. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ- myctransgenic mice[J]. Cell, 1991 ;65 ( 5 ) :753-63.
  • 2Vonlanthen S, Heighway J, Altermatt HJ, et al. The Bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression[J].Br J Cancer,2001 84:1372-6.
  • 3van Kemenade FJ, Raaphorst FM, Blokzijl T,et al. Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling ceils and degree of malignancy in B-cell non-Hodgkin lymphoma[J].Blood,
  • 4Kim JH, Yoon SY, Kim CN, et al. The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p161NK4a/ p14ARF proteins [J]. Cancer Lett,2004 ; 203 ( 2 ) : 217 -24.
  • 5Reinisch C, Kandutsch S, Uthman A, et al. BMI-1 :a protein expressed in stem cells,specialized cells and tumors of the gastrointestinal tract [J].Histol Histopathol,2006 ;21 : 1143-9.
  • 6龚辉,张义成,刘文励.Bmi-1基因调控造血干细胞自我更新的研究进展[J].中国实验血液学杂志,2006,14(2):413-415. 被引量：11
  • 7刘卫红,孟秀香,刘丹丹,单路娟,赵心宇.反义Bmi-1对Jurkat细胞的抑制作用[J].中华血液学杂志,2005,26(9):554-556. 被引量：19
  • 8Gould A. Function analysis of mouse polycomb group and tfithorax group related gene[J]. Curr Opin Genet Dev, 1997 ;7 (4) :488-94.
  • 9Itahana K, Zou Y, Itahana Y, et al. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1[J]. Mol Cell Biol,2003 ;23 ( 1 ) :389-401.
  • 10Song LB, Zeng MS, Liao WT, et al. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells [J].Cancer Res, 2006 ; 66 ( 12 ) : 6225- 32.

二级参考文献21

  • 1Park IK, He Y, Lin F, et al. Differential gene expression profiling of adult murine hematopoietic stem cells. Blood ,2002,99:488-498.
  • 2Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature, 2003,423:255-260.
  • 3Jacobs JJ, Kieboom K, Marino S, et al. The oncogene and polycombgroup gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature, 1999,397:164-168.
  • 4Park IK, Qian D, Kiel M, et al. Bmi-1 is required for maintenance of adult self-renewing hematopoietic stem cells. Nature, 2003,423:302-305.
  • 5Blyth K, Terry A, O H ara M, et al. Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss. Oncogene,1995,10:1717-1723.
  • 6Bodrug SE, Warner BJ, Bath ML, et al. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO, 1994,13:2124-2130.
  • 7van-der-Lugt NM,Domen J,Linders K,et al.Posterior transformation,neurological abnormalities,and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.Genes Dev,1994; 8:757-769.
  • 8Jacobs JJ,Scheijen B,Voncken JW,et al.Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.Genes Dev,1999; 13:2678-2690.
  • 9Jacobs JJ,Kieboom K,Marino S,et al.The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senesecence through the ink4a locus.Nature,1999; 397(6715):164-168.
  • 10Ezoe S,Matsumura I,Satoh Y,et al.Cell cycle regulation in hematopoietic stern/progenitor cells.Cell Cycle,2004; 3:314-318.

共引文献24

同被引文献43

  • 1冯艳,宋立兵,郭宝红,廖雯婷,李满枝,刘万里,曾木圣,张玲.Bmi-1在乳腺癌组织中的表达及意义[J].癌症,2007,26(2):154-157. 被引量：67
  • 2王琛,李徐生,徐小东,吕西.腹腔镜外科技术在结肠癌治疗中的临床应用[J].中国普外基础与临床杂志,2007,14(6):644-645. 被引量：8
  • 3Parkin D M.Global cancer statistics in the year 2000[J].Lancet Oncol,2001,58(2):533-543.
  • 4Li D W,Tang H M,Fan J W,et al.Expression level of Bmi-1oncoprotein is associated with progression and prognosis in colon cancer[J].J Cancer Res Clin Oncol,2010,136(7):997-1006.
  • 5Reya T,Morrison S J,Clarke M F.Stem cells,cancer and cancer stem cells[J].Nature,2001,414(6859):105-111.
  • 6Haraguchi N,Inoue H,Tanaka F,et al.Cancer stem cells in human gastrointestinal cancers[J].Hum Cell,2006,25(19):24-29.
  • 7O’Brien C A,Pollett A,Gallinger S,et al.A human colon cancer cell capable of initiating tumour growth in immunodeficient mice[J].Nature,2007,445(58):106-110.
  • 8Song W,Tao K,Li H,et al.Bmi-1 is related to proliferation,survival and poor prognosis in pancreatic cancer[J].Cancer Sci,2010,101(7):1754-1760.
  • 9Wu J,Hu D,Yang G,et al.Down-regulation of BMI-1 cooperates with artemisinin on growth inhibition of nasopharyngeal carcinoma cells[J].J Cell Biochem,2011,112(7):1938-1948.
  • 10Li H,Song F,Chen X,et al.Bmi-1 regulates epithelial-tomesenchymal transition to promote migration and invasion of breast cancer cells[J].Int J Clin Exp Pathol,2014,7(6):3057-3064.

引证文献5

二级引证文献22

中国老年学杂志
2008年 第22期

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