摘要
目的:运用Meta-分析评价TNF-α基因基因多态性与同种异体肾移植急性排斥反应发生风险的关系。方法:检索Medline、Embase和中国生物医学文献数据库(CBM)。纳入相关TNF-α基因-308位点基因多态性与同种异体肾移植急性排斥反应关系的队列研究和病例-对照研究。所有数据分析使用RevMan 4.2软件进行统计分析。结果:TNF-α基因-308位点高分泌型基因在肾同种异体排斥组中较非排斥组高(OR=1.89,95%CI=1.30～2.72,P=0.000 7),但各研究间存在显著异质性(Q=28.35,df=13,P=0.008)。进一步分层分析显示:中国人TNF-α基因-308位点高分泌型基因在肾同种异体排斥组中较非排斥组高(OR=3.15,95%CI=1.96～5.08,P<0.000 01);西方人群TNF-α基因-308位点高分泌型基因在肾同种异体排斥组中较非排斥组高(OR=1.32,95%CI=1.02～1.70,P=0.004);白种人TNF-α基因-308位点高分泌型基因在肾同种异体排斥组中较非排斥组高(OR=1.32,95%CI=1.01～1.73,P=0.04);而黑种人TNF-α基因-308位点高分泌型基因在肾同种异体排斥组中较非排斥组无明显差异(OR=1.38,95%CI=0.68～2.81,P=0.37)。结论:TNF-α基因型可能是影响同种异体肾移植急性排斥的重要因素,但样本量不足,需更大样本研究确证此结果。
Objective： To assess the association between TNF-α gene-308 polymorphism and renal allograft acute rejection using the methods of meta-anlysis. Methods： All cohort studys and case-control studys involving in the association between TNF-α-308 polymorphism and renal allograft acute rejection were retrieved through the computerized Medline, Embase and CBM. All of datas were analyzied using RevMan 4.2 software. Results： The TNF-α high gene frequencies of A/A or A/G were significantly higher in the risks of renal allograft acute rejection （OR =1.89, 95% CI = 1.30 - 2.72, P =0. 0007）, but all of studys existed significant heterogeneity （Q = 28.35,df = 13, P =0. 008）. Further sub-group analyzing show that the TNF-α high gene frequencies of A/A or A/G of Chinese were significantly higher in the risks of renal allograft acute rejection （OR =3.15, 95% CI = 1.96-5.08, P〈0. 00001）. As well as the western group and caucasians （OR =1.32, 95% CI = 1.02-1.70, P =0. 004）, （OR =1.32, 95% CI = 1.01-1.73, P =0.04）, but there was not significant difference in black group （OR =1.38, 95% CI = 0.68 - 2.81, P =0.37）. Conclusion： The TNF-α gene-308 polymorphism might be a genetic risk factor for renal allograft acute rejection, but because of not enough samples, we must further identify the result by big sample study.
出处
《新疆医科大学学报》
CAS
2008年第11期1519-1524,共6页
Journal of Xinjiang Medical University
