摘要
目的:探讨EN对食管癌病人术后应激反应和肠道屏障功能的影响。方法:将54例食管癌切除术病人随机分成PN组(n=28例)和EN组(n=26例)。分别检测手术前后不同时段的血清细胞因子、T细胞亚群、NK细胞活性、蛋白质和内毒素水平等。结果:血清ALB、PA和FT等营养指标术后均显著降低,但两组间差异无显著性意义。术后第1和第3天,两组病人血清IL-6水平较术前均显著升高(P<0.01),EN组显著低于PN组。血清IL-10与IL-6变化相似。术后两组CD3+、CD4+、CD4+/CD8+均显著降低(P<0.01),术后第10天EN组显著高于PN组(P<0.05)。术后第10天EN组NK细胞活性明显超过PN组。EN组血清内毒素水平术后显著低于PN组(P<0.05)。结论:EN支持对食管癌术后病人能减少血清内毒素、抑制过度炎症反应和维持机体免疫功能。
Objective ： The purpose of the study was to investigate the effects of enteral nutrition on stress response and gut barrier function after surgery for esophageal cancer. Methods ： Patients who underwen＇t esophagectomy were divided into two groups. Group PN （28 patients） served as the control group. Group EN （26 patients） received enteral nutrition. Results： The serum total protein, albumin, prealbumin and transferrin decreased after operation, but there were no differences between the two groups. The serum levels of IL-6 were significantly higher on the first and third postoperative days after the operation in two groups （P 〈 0.01 ）. IL-6 in group EN was significantly lower in group PN. The serum concentration of IL-10 was similar to IL-6. CD3 ＋ ,CD4＋and CD4＋/CD8 ＋ significantly decreased postoperatively in both groups （P 〈 O. 05 ）, and the values in group EN were significantly higher than in group PN on the 3rd postoperative day （P 〈 0.05 ）. NK cell activity in group EN was significantly higher than group PN on the 10th postoperative day （P 〈 0.05 ）. The serum endotoxin concentration was significantly lower in group EN after the operation than group PN （P 〈 0.05）. Conclusion ： Perioperative EN can reduce the stress response and prevente stress-induced immunosuppression following esophagectomy.
出处
《肠外与肠内营养》
CAS
2008年第6期350-353,共4页
Parenteral & Enteral Nutrition
