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白细胞介素-8 mRNA与反复自然流产的相关性 被引量:7

Correlation of interleukin-8 mRNA with recurrent spontaneous abortion
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摘要 目的:探讨反复自然流产患者绒毛、蜕膜和外周血单个核细胞白细胞介素-8(IL-8)mRNA的表达与反复自然流产的相关性。方法:采用半定量逆转录-聚合酶链反应(RT-PCR)技术,检测30例反复自然流产患者(病例组)和30例正常妊娠妇女(对照组)绒毛、蜕膜及外周血单个核细胞内IL-8 mRNA表达水平的相对含量(%)。结果:在绒毛组织中,病例组IL-8 mRNA的表达明显高于对照组;在蜕膜组织中,病例组IL-8 mRNA的相对含量为(68.57±4.73)%,对照组的为0;在外周血单个核细胞中,病例组IL-8 mRNA的表达高于对照组。结论:病例组绒毛、蜕膜组织及外周血单个核细胞中IL-8 mRNA表达水平显著升高,提示IL-8可能与反复自然流产相关。 Objective:To investigate the expression of interleukin-8 (IL-88) mRNA in villi, decidua and peripheral blood mononuelear cells (PBMCs) of patients with recurrent spontaneous abortion (RSA). Methods:The expressions of IL-88 mRNA in villi, decidua and PBMCs of 30 RSA patients, as well as 30 normal pregnant women were measured by semiquatitative transcriptional polymerase chain reaction (RT-PCR). Results: In villi, the expression of IL-88 mRNA was signifi- cantly higher in RSA group than that in the control group. In decidua of RSA, the level of IL-88 mRNA was (68.57±4.73)%, and that was zero in the controls. Conclusion: The high expression of IL-8 mRNA in villi, decidua and PBMCs is releated to RSA.
出处 《解剖学杂志》 CAS CSCD 北大核心 2008年第6期802-804,共3页 Chinese Journal of Anatomy
基金 内蒙古自治区教育厅资助(NJ04018)
关键词 白细胞介素-8 反复自然流产 聚合酶链反应 interleukin 8 recurrent spontaneous abortion polymerase chain reaction
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  • 1齐卫红,蒋凤兰,詹瑛.IL-10、IL-8在习惯性流产患者外周血及母胎界面中的表达[J].现代医药卫生,2006,22(11):1599-1600. 被引量:9
  • 2刘以训.颗粒细胞分泌一种刺激卵母细胞组织型纤蛋白溶酶原激活因子的物质[J].中国科学:B辑,1989,(10):1050-1055.
  • 3Kimatrai M,Blanco O,Munoz-Fe Rnandez R,et al.Contractile Activity of Human Decidual Stromal Cells Ⅱ.Effect of Interleukin-10[J].J Clin Endocrinol Metab,2005,16:[Epub ahead of print].
  • 4Hill JA,Polgar k,Anderson DJ,et al.T-heiper Ⅰ-typer imunty to trophoMast in woman with recurrent spontaneous abortion[J].JAMA,1997,273(24):1933.
  • 5Shimoya K,Matsuzaki N,Taniguchi T,et al.Human placenta constitutively produces mterleulin-8 dueing pregnancy and enhances its production in intrauterine infaction[J].Biol Reprod,1992,47:220.
  • 6Paradisi R,Porcu E,Venturoli S,et al.Maternal serum levels of proinflammatory cytokines in missed and threatened abortion [J].Am J Reprod Immunol,2003,50(4):302.
  • 7Lin H,Mosmann T R,Guilbert L,et al.Synthesis of T helper 2 type cytokines at the maternal-fetal interface[J].J Immunol,1993,151(9):4562-4573.
  • 8Marzi M,Vigano A,Trabattoni D,et al.Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy[J].Clin Exp Immunol,1996,106(1):127-133.
  • 9Raghupathy R.Th1-immunity is incompatible with successful pregnancy[J].Immunol Today,1997,18(10):478-482.
  • 10Piccinnim P,Beloni L,Livi C,et al.Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions[J].Nat Med,1998,4(9):1020-1024.

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