摘要
目的:评价单剂量阿托伐他汀对兔急性心肌梗死(AMI)再灌注内皮素-1(ET-1)及无复流的影响。方法:新西兰大白兔24只随机分成对照组、阿托伐他汀组(治疗组,10mg/kg)和假手术组。冠状动脉结扎1h,松解2h制备AMI再灌注模型。采用放射免疫法测定血浆及心肌ET-1的含量,最终行病理学分析。结果:与对照组相比,阿托伐他汀显著降低AMI再灌注后血浆ET-1的水平(P<0.01);而心肌组织ET-1的含量治疗组仅复流区显著降低(P<0.01)。治疗组与对照组相比,无复流范围显著减少(P<0.01)。结论:单剂量阿托伐他汀具有内皮保护作用,能有效防治AMI再灌注后无复流的发生。
Objective To evaluate the effects of one-dose atorvastatin on endothelin-1 （ET-1 ） and myocardial no-reflow in rabbits with acute myocardial infarction （AMI） reperfusion. Methods twenty-four rabbits were randomized into 3 groups：control group, atorvastatin-treated group （10 mg/kg） and sham-operated group. AMI reperfusion rabbits were established by coronary artery occlusion for 1 hour followed reperfusion for 2 hours. The levels of ET-1 in plasma and myocardium were determined by radioimmunoassay. Results Atorvastatin significantly reduced the plasma ET-I levels after AM/reperfusion （P 〈 0.01 ）, whereas the myocardium ET-1 levels significantly decreased only in infarcted reflow area （P 〈 0.01 ）. The mean area of no-reflow in atorvastatin group was significantly lower than that in the control group （P 〈 0.01）. Conclusions One-dose atorvastatin is effective in protection of endothelial cells,and it has a beneficial effect on preventing myocardial no-reflow during acute myocardial infarction reperfusion in rabbits.
出处
《实用医学杂志》
CAS
2008年第22期3833-3835,共3页
The Journal of Practical Medicine
