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系统性红斑狼疮肺间质病变的临床特征 被引量:12

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摘要 目的:探讨系统性红斑狼疮(SLE)患者肺间质病变(ILD)的发生率及临床特征。方法:对住院治疗的152例SLE伴ILD患者进行回顾性分析。结果:1350例SLE患者中,发生ILD152例,发生率为11.3%。临床表现有气促、发热、干咳、肺部听诊湿罗音等,73例(48.0%)无呼吸系统症状体征。70例患者(46.1%)X线胸片表现有异常。肺高分辨率CT扫描(HRCT)检查最常见表现是磨玻璃影,发生率46.7%;其次为网状影和小叶间隔增厚,发生率分别为36.8%和31.6%。68例(44.7%)患者肺功能异常,表现为限制性通气功能障碍和换气功能障碍。16例(10.5%)出现低氧血症。ILD组与非ILD组SLE疾病活动指数积分差异无显著性。结论:SLE伴ILD并不少见。肺HRCT对ILD的诊断和评价有重要价值。对于早期ILD,尚无临床症状及胸片异常时,通过肺HRCT和肺功能测定对肺的形态和功能进行全面评估,有助于早期诊断和及时治疗,阻止肺间质纤维化的发生,改善预后。
出处 《实用医学杂志》 CAS 2008年第22期3906-3907,共2页 The Journal of Practical Medicine
基金 广东省科技计划基金资助项目(编号:2005B30701001)
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