摘要
研究了以α-D-葡萄糖为原料,经异丙叉基保护、甲基化、苯亚甲基化等步骤合成了3-O-甲基-4,6-O-苯亚甲基-N-(2-吡啶基)-α-D-葡萄糖,产物经质谱、核磁共振谱及红外光谱对其进行了结构表征分析。N-杂环取代的糖类化合物是一种重要的医药和有机合成中间体,该类化合物将在合成糖基、核苷类似物、杂环化合物、糖多肽等具有潜在药理活性的化合物中具有广阔的应用前景.
The paper researches on a novel method for the synthesis of 3-O-methyl-4, 6-O-benzylidene-N-（g-pyridyl）-α-D-glucopyranosylamine by using D-glucose as the starting material through multi-step and the product is synthesized and characterized by MS, NMR, IR first time. The 3-O-methyl-4, 6-O-benzylidene-N-（2-pyridyl）-α-D-glucopyranosylamine is an important pharmaceutical and organic intermediate which could serve as versatile intermediates for the synthesis of glycosyl derivatives such as thioureas, nucleosides, heterocyclic compounds, polypeptide, etc.
出处
《杭州师范大学学报（自然科学版）》
CAS
2008年第6期449-452,共4页
Journal of Hangzhou Normal University(Natural Science Edition)
基金
浙江省自然科学基金人才(省杰出青年团队)资助项目(R406378)
